
%0 Journal Article
%A Barlin, GB 
%A Davies, LP 
%A Ireland, SJ 
%A Zhang, JK 
%T Imidazo[1,2-b]pyridazines. XIV. Syntheses and Central Nervous System Activities of Some 6-(Methoxy-, dimethoxy-, methylenedioxy-, chloro- and fluoro-)-3-alkoxy-2-phenyl(and substituted phenyl)imidazo[1,2-b]pyridazines
%J Australian Journal of Chemistry
%D 1993/03/01
%V 46
%N 3
%P 353-361
%K 
%R https://doi.org/10.1071/CH9930353
%U https://www.publish.csiro.au/paper/CH9930353 
%X Syntheses are reported for 28 new 3-alkoxy-6-(3&#8242;-methoxy-,3&#8242;,4&#8242;-dimethoxy, 3&#8242;,4&#8242;-methylene-dioxy-, 2&#8242;- and 4&#8242;-chloro- and 4&#8242;-fluoro-benzylamino)-2-phenyl(and substituted phenyl) imidazo -[1,2-b] pyridazines from the corresponding 6-substituted pyridazin-3-amine 2-oxides with &#945;- bromoacetophenones, followed by alkylation of the intermediate 3-hydroxyimidazo[1,2-b] pyridazines. In tests of the ability of these compounds to displace [3H]diazepam from rat brain membrane, 3-(2&#8242;-ethoxyethoxy)-6(3&#8242;-methoxybenzylamino)-2-phenyl- and 6(3&#8242;,4&#8242;-methylenedioxybenzylamino )-2-(3&#8243;,4&#8243;-methylenedioxyphenyl)-3-methoxy-imidazo[1,2-b] pyridazine bound most strongly, with IC50 values of 1nM. 
