
%0 Journal Article
%A Chiu, FCK 
%A Brownlee, RTC 
%A Phillips, DR 
%T Cupric Ion Chelation Assisted Synthesis of N(<sup>&#945;</sup>)-Protected N(<sup>&#969;</sup>)-Acridin-9-yl &#945;,&#969;-Diamino Carboxylic Acids
%J Australian Journal of Chemistry
%D 1993/08/01
%V 46
%N 8
%P 1207-1212
%K 
%R https://doi.org/10.1071/CH9931207
%U https://www.publish.csiro.au/paper/CH9931207 
%X The synthesis of N&#945;-protected N&#969;-acridin-9-yl derivatives of the &#945;,w-diamino carboxylic acids ornithine and lysine is reported. Direct introduction of the acridin-9-yl moiety to the amino side chain of the free amino acid was achieved in methanol through temporary copper(II) chelation protection of the &#945;-amino and carboxy groups. N&#945;-Fmoc protection was introduced by using N-(fluoren-9-ylmethoxycarbonyloxy)succinimide in aqueous dioxan. 
