
TY  - JOUR
A1  - Pereira, SM 
A1  - Savage, GP 
A1  - Simpson, GW 
A1  - Greenwood, RJ 
A1  - Mackay, MF 
T1  - Diastereoselective Propionitrile Oxide Cycloaddition Reactions With Some &#947;-Substituted &#945;-Methylene-&#947;-butyrolactones
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1993
VL  - 46
IS  - 9
SP  - 1401
EP  - 1412
KW  - 
UR  - https://doi.org/10.1071/CH9931401 
N2  - A number of &#947;-substituted &#945;-methylene-&#947;-butyrolactone derivatives underwent 1,3-dipolar cycloaddition with propionitrile oxide to give spiro &#916;2-isoxazolines. The reaction proceeded regiospecifically and with high diastereoselectivity. The products of anti addition predominated. The regiochemistry of addition and relative stereochemistry of the products were determined by a combination of n.O.e ., HETCOR and DOUBTFUL n.m.r. experiments. The assignment was confirmed in one case by X-ray crystallography. 
ER  -

