
%0 Journal Article
%A Barlin, GB 
%A Ireland, SJ 
%A Nguyen, TMT 
%A Kotecka, B 
%A Rieckmann, KH 
%T Potential Antimalarials. XVIII. Some Mono- and Di-Mannich Bases of 3-[7-Chloro(and trifluoromethyl)quinolin-4-ylamino]phenol
%J Australian Journal of Chemistry
%D 1993/11/01
%V 46
%N 11
%P 1685-1693
%K 
%R https://doi.org/10.1071/CH9931685
%U https://www.publish.csiro.au/paper/CH9931685 
%X Syntheses are reported for mono- and di-Mannich base derivatives of 3-[7-chloro(and trifluoro-methyl)quinolin-4-ylamino]phenols by Mannich reaction on 3-[7-chloro(and trifluoromethyl )-quinolin-4-ylamino]phenols or by condensation of Mannich base derivatives of 3-aminophenol, prepared from 3-nitrophenol, with the appropriate 4-chloroquinoline. The antimalarial activity of 3-(7&#8242;-chloroquinolin-4&#8242;-ylamino)-2,6-bis[ pyrrolidin-1&#8243;-ylmethyl -(or piperidin-1&#8243;-ylmethyl)]phenol against the FC-27 isolate of Plasmodium falciparum was comparable to that of chloroquine, and it was not significantly diminished in tests against the chloroquine -resistant K-1 isolate. 
