
TY  - JOUR
A1  - Cookson, PD 
A1  - Tiekink, ERT 
A1  - Whitehouse, MW 
T1  - Phosphinegold(I) Complexes Containing the Purine-6-thiolate Anion, and Their Antiarthritic Activity
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1994
VL  - 47
IS  - 4
SP  - 577
EP  - 586
KW  - 
UR  - https://doi.org/10.1071/CH9940577 
N2  - A series of complexes of the general formulae R3PAu(6-mp), R3P = Et3P, Ph3P, Cy3P, PhMe2P, (o-tol)3P, (m-tol)3P or (p-tol)3P, (AuCl)Ph2P(CH2)nPPh2(Au(6-mp)), n = 2 or 3, and Ph2P(CH2)nPPh2(Au(6-mp))2, n = 1, 2 or 3 and 6-mp is the anion derived from 6-mercaptopurine (purine-6-thiol), have been prepared and characterized by spectroscopic methods (i.r., 1H, 13C, 31P n.m.r. and f.a.b. m.s.) and, in the case of the Ph3PAu(6-mp) complex, by single-crystal X-ray diffraction methods. The spectroscopic data show that the 6-mp ligand coordinates as a thiolate ligand and that the gold atoms exist in linear P-Au-S (or P-Au-Cl) geometries. This has been confirmed by an X-ray study on Ph3PAu(6-mp), isolated as an ethanol solvate; the study shows the gold atom to be linearly coordinated by the phosphorus and sulfur atoms: Au-P(1) 2.237(2), Au-S(6) 2.287(1) &#506; and P-Au-S 173.71(6)&#176;. Crystals of Ph3PAu(6-mp).EtOH are triclinic, space group P&#299;, with unit cell dimensions a 11.066(3), b 13.552(3), c 8.705(2) &#506;, &#945; 91.51(2), &#946; 113.06(2), &#947; 89.69(2)&#176;, V 1200.8(5) &#506;3, Z 2. The structure was refined by a full-matrix least-squares procedure to R 0.034 for 3978 reflections with I &#8805; 3.0&#963;(I). Preliminary results of testing for antiarthritic activity among the new complexes in rats are also reported showing that some of them are more potent/less toxic than current gold(I) thiolates used clinically. 
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