
%0 Journal Article
%A Bawrlin, GB 
%A Ireland, SJ 
%A Nguyen, TMT 
%A Kotecka, B 
%A Rieckmann, KH 
%T Potential Antimalarials. XX. Mannich Base Derivatives of 2-[7-Chloroquinolin-4-ylamino and 7-Bromo(and 7-trifluoromethyl)-1,5-naphthyridin-4-ylamino]-4-chloro(or 4- or 6-t-Butyl or 4- or 5-fluoro)phenols and 4(or 6)-t-Butyl-2-(7-trifluoromethylquinolin-4-ylamino)phenol
%J Australian Journal of Chemistry
%D 1994/06/01
%V 47
%N 6
%P 1143-1154
%K 
%R https://doi.org/10.1071/CH9941143
%U https://www.publish.csiro.au/paper/CH9941143 
%X Syntheses are reported for some mono- and di-Mannich base derivatives of 4-chloro-, 3- or 4-fluoro-, or 2- or 4-t-butyl-substituted 2-(7&#8242;-chloroquinolin-4&#8242;-ylamino)phenols and 2-[7&#8242;-bromo(and 7&#8242;-trifluoromethyl)-1&#8242;,5&#8242;-naphthyridin-4&#8242;-ylamino]phenols. In tests against the FC-27 isolate of Plasmodium falciparum, the most active compound was 2-(7&#8242;-chloroquinolin-4&#8242;-ylamino)-5-fluoro-4,6-bis(piperidin-1&#8242;-ylmethyl)phenol (16) with IC50 12.2 nM. 
