
TY  - JOUR
A1  - Bernhardt, PV 
A1  - Comba, P 
A1  - Elliott, BL 
A1  - Lawrance, GA 
A1  - Maeder, M 
A1  - Oleary, MA 
A1  - Wei, G 
A1  - Wilkes, EN 
T1  - Metal-Directed Synthesis of Macrocyclic Tetraamines With Pendant Nitro or Amine Groups, Based on <I>trans</I>-Cyclohexane-1,2-diamine
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1994
VL  - 47
IS  - 6
SP  - 1171
EP  - 1178
KW  - 
UR  - https://doi.org/10.1071/CH9941171 
N2  - Reaction of R,R:S,S-, R,R:R,R(or S,S:S,S)- bis (trans-cyclohexane-1,2-diamine)copper(II) with formaldehyde and nitroethane in aqueous base yields the macrocyclic molecular cation (4,15-dimethyl-4,15-dimethyl-4,15-dinitro-2,6,13,17-tetraazatricyclo[16.4.0.07,12] docosane )copper(II) with two -NH-CH2-C(Me)(NO2)-CH2-NH-links completing the macrocycle, as well as the molecular cation [N,N&#8242;- bis (2-aminocyclohexyl)-2-methyl-2-nitropropane-1,3-diamine]copper(II) with a single such link inserted. The rigid polycylic macrocycle , based on a 14-membered tetraazacycloalkane ( cyclam ) frame, may exist as a number of isomers. Spectroscopic and chiroptical properties of the isolated complexes are reported. Reduction of the nitro groups with zinc in aqueous acid produces the corresponding molecules with primary amine (or ammonium) pendants in good yield, as metal-free hydrochloride salts. 
ER  -

