
%0 Journal Article
%A Gray, JE 
%A Maclean, SA 
%A Reinsborough, VC 
%T Limitations of the Phenolphthalein Competition Method for Estimating Cyclodextrin Binding Constants
%J Australian Journal of Chemistry
%D 1995/03/01
%V 48
%N 3
%P 551-556
%K 
%R https://doi.org/10.1071/CH9950551
%U https://www.publish.csiro.au/paper/CH9950551 
%X The phenolphthalein competitive spectrophotometric technique was used to obtain binding constants for cyclodextrin complexes for a variety of both inclusates and cyclodextrins . The former included alkane-1-sulfonates (C5-C12), alkyl sulfates (C6, C8, C12) and several heterocyclic ligands, and the latter included &#946;-cyclodextrin, dimethyl-&#946;-cyclodextrin and &#947;- cyclodextrin . The technique was not successful for either &#945;- cyclodextrin or trimethyl -&#946;- cyclodextrin inclusion complexes, or with many primary amines and quaternary ammonium cationic surfactants. However, for many colourless inclusates this method is a simple, convenient, reliable route to cyclodextrin binding constants. 
