
%0 Journal Article
%A Badran, TW 
%A Chai, CLL 
%A Easton, CJ 
%A Harper, JB 
%A Page, DM 
%T Directing Bromination of Piperazine-2,5-diones
%J Australian Journal of Chemistry
%D 1995/07/01
%V 48
%N 7
%P 1379-1384
%K 
%R https://doi.org/10.1071/CH9951379
%U https://www.publish.csiro.au/paper/CH9951379 
%X From intermolecular and intramolecular competition experiments, it has been established that, by comparison with an N-methyl substituent, an N-acetyl group deactivates glycine residues in piperazine-2,5-diones towards free-radical bromination. Combined with the ease of introduction and removal of N-acetyl substituents, the deactivating effect provides a method for regiocontrolled functionalization of these compounds. 
