
%0 Journal Article
%A Caiazza, D 
%A Prager, RH 
%A Schafer, K 
%T The Chemistry of 5-Oxodihydroisoxasoles. XIV. Synthesis of 2-(1-Aryltetrazol-5-yl)propanoic Acids
%J Australian Journal of Chemistry
%D 1995/11/01
%V 48
%N 11
%P 1861-1872
%K 
%R https://doi.org/10.1071/CH9951861
%U https://www.publish.csiro.au/paper/CH9951861 
%X A number of N-arylisoxazol-5(2H)-ones (aryl = phenyl, isoquinolin-1-yl, quinolin-2-yl, 2-phenylquinazolin-4-yl and benzothiazol-2-yl) have been reacted with lithium azide to give 2-(1-aryltetrazol-5-yl)acetic esters, which have been C- methylated and hydrolysed. The resulting 2-(1-aryltetrazol-5-yl) propanoic acids had low antiinflammatory activity, as judged by inhibition of synthesis of prostaglandin PGE2 or tumour necrosis factor &#945;. 
