
TY  - JOUR
A1  - Kim, J 
A1  - Lindoy, LF 
A1  - Matthews, OA 
A1  - Meehan, GV 
A1  - Nachbaur, J 
A1  - Saini, V 
T1  - New Macrocyclic Ligands. VII. The Synthesis of Mixed-Donor Spiro-Linked Macrocycles
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1995
VL  - 48
IS  - 12
SP  - 1917
EP  - 1924
KW  - 
UR  - https://doi.org/10.1071/CH9951917 
N2  - The syntheses of five new spiro -linked bis-macrocyles, incorporating four ether oxygen and four or six secondary nitrogen heteroatoms , are reported. Two strategies were employed-the first involved the condensation of a spiro tetraaldehyde with 2 equiv. of ethane-1,2-diamine or propane-1,3-diamine or 2,2&#8242;-diaminodiethylamine followed by in situ reduction of the resulting intermediate tetraimines . The second procedure began with pentaerythrityl  tetraamine [C(CH2NH2)4] which was then condensed with 2 equiv. of a dialdehyde moiety in which two ether oxygen atoms, bridged by either two or three methylene groups, were incorporated in its backbone. A related in situ reduction step to that employed in the first procedure then yielded the required double-ring macrocycles. For use in comparative studies, the corresponding single-ring macrocycles were also synthesized where they had not been reported previously. 
ER  -

