
%0 Journal Article
%A Brown, CL 
%A Harding, MM 
%A Krippner, GY 
%A Rainone, S 
%A Webster, LK 
%T Preparation and Biological Activity of Heteroaryl-Substituted Bile Steroids
%J Australian Journal of Chemistry
%D 1996/01/01
%V 49
%N 1
%P 7-11
%K 
%R https://doi.org/10.1071/CH9960007
%U https://www.publish.csiro.au/paper/CH9960007 
%X The synthesis, and growth inhibition studies against the L1210 mouse leukaemia,  MCF-7 human breast cancer and SKOV-3 ovarian carcinoma cell lines, of derivatives of lithocholic acid and cholic acid in which quinoline-3-carboxylate and acridine-9-carboxylate are substituted at the 3 and/or the 24 position are reported. The 3&#945;,24-diheteroaryl-substituted steroid systems, lithocholic acid, cholic acid, quinoline and acridine-9-carboxylic acid showed no significant biological activity against any of the cell lines. In contrast, when either a single quinoline-3-carboxylate or acridine-9-carboxylate unit is substituted onto position 24 of the steroid derivatives, significant activity against L1210, and weak activity against the MCF-7 and SKOV-3 lines is exhibited. DNA thermal denaturation studies of these compounds showed no detectable binding to calf thymus DNA. 
