
TY  - JOUR
A1  - Brown, CL 
A1  - Harding, MM 
A1  - Krippner, GY 
A1  - Rainone, S 
A1  - Webster, LK 
T1  - Preparation and Biological Activity of Heteroaryl-Substituted Bile Steroids
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1996
VL  - 49
IS  - 1
SP  - 7
EP  - 11
KW  - 
UR  - https://doi.org/10.1071/CH9960007 
N2  - The synthesis, and growth inhibition studies against the L1210 mouse leukaemia,  MCF-7 human breast cancer and SKOV-3 ovarian carcinoma cell lines, of derivatives of lithocholic acid and cholic acid in which quinoline-3-carboxylate and acridine-9-carboxylate are substituted at the 3 and/or the 24 position are reported. The 3&#945;,24-diheteroaryl-substituted steroid systems, lithocholic acid, cholic acid, quinoline and acridine-9-carboxylic acid showed no significant biological activity against any of the cell lines. In contrast, when either a single quinoline-3-carboxylate or acridine-9-carboxylate unit is substituted onto position 24 of the steroid derivatives, significant activity against L1210, and weak activity against the MCF-7 and SKOV-3 lines is exhibited. DNA thermal denaturation studies of these compounds showed no detectable binding to calf thymus DNA. 
ER  -

