
%0 Journal Article
%A Matyus, P 
%A Barlin, GB 
%A Harrison, PW 
%A Wong, MG 
%A Davies, LP 
%T Ligands for the Central Benzodiazepine Receptor: Structure&#8211;Affinity Relationship Studies on Imidazo[1,2-b]pyridazines
%J Australian Journal of Chemistry
%D 1996/04/01
%V 49
%N 4
%P 435-442
%K 
%R https://doi.org/10.1071/CH9960435
%U https://www.publish.csiro.au/paper/CH9960435 
%X Seventy-six imidazo [1,2-b] pyridazines and some bicyclic isomers have been analysed and compared in terms of geometric and electronic requirements for binding to central benzodiazepine receptors. The binding sites identified for these compounds by molecular modelling are consistent with known benzodiazepine receptor- ligand interaction models. However, for the most active compounds, additional binding sites are proposed. 
