
%0 Journal Article
%A Barlin, GB 
%A Kotecka, B 
%A Rieckmann, KH 
%T Potential Antimalarials. XXII. Some 2,4-Diamino-5-(3- and 4-trifluoromethylphenyl and 3,4-methylenedioxyphenyl)pyrimidines
%J Australian Journal of Chemistry
%D 1996/06/01
%V 49
%N 6
%P 647-650
%K 
%R https://doi.org/10.1071/CH9960647
%U https://www.publish.csiro.au/paper/CH9960647 
%X A series of 10 pyrimethamine analogues containing 3'- and 4'-trifluoromethyl and 3',4'-methylenedioxy groups has been prepared and tested for in vitro antimalarial activity against the FC-27 and K-1isolates of Plasmodium falciparum. Several of these compounds were almost as active as pyrimethamine against the drug-sensitive FC-27 isolate, and like pyrimethamine , they were much less active against the drug-resistant K-1 isolate. The 4'-trifluoromethyl compunds, however, showed much smaller differences. 
