
TY  - JOUR
A1  - Barlin, GB 
A1  - Kotecka, B 
A1  - Rieckmann, KH 
T1  - Potential Antimalarials. XXII. Some 2,4-Diamino-5-(3- and 4-trifluoromethylphenyl and 3,4-methylenedioxyphenyl)pyrimidines
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1996
VL  - 49
IS  - 6
SP  - 647
EP  - 650
KW  - 
UR  - https://doi.org/10.1071/CH9960647 
N2  - A series of 10 pyrimethamine analogues containing 3'- and 4'-trifluoromethyl and 3',4'-methylenedioxy groups has been prepared and tested for in vitro antimalarial activity against the FC-27 and K-1isolates of Plasmodium falciparum. Several of these compounds were almost as active as pyrimethamine against the drug-sensitive FC-27 isolate, and like pyrimethamine , they were much less active against the drug-resistant K-1 isolate. The 4'-trifluoromethyl compunds, however, showed much smaller differences. 
ER  -

