
TY  - JOUR
A1  - Gazzola, C 
A1  - Lindsay, DB 
T1  - A study of bovine proteoglycan-II as a growth promotant
JF  - Australian Journal of Agricultural Research
JO  - Aust. J.  Agric. Res.
Y1  - 1993
VL  - 44
IS  - 2
SP  - 221
EP  - 228
KW  - cattle;proteoglycans;peptide growth factors;rats
UR  - https://doi.org/10.1071/AR9930221 
N2  - Proteoglycan-II is a dermatan sulfate proteoglycan which binds peptide growth factors, and through this mechanism it has been shown to alter the growth of mammalian cells in culture. The possibility was tested that injections of proteoglycan-II could alter the growth of live animals. Proteoglycan-II from bovine occipital condyle articular cartilage was prepared, authenticated and injected into male Wistar rats. The injection of 125I-proteoglycan-II showed that it was absorbed and metabolized by the rats. Growth studies showed that treatment with proteoglycan-II at two levels of purity and at two dose rates produced no change (P > 0.05) in live weight gain, body composition or food conversion efficiency. 
ER  -

