
TY  - JOUR
A1  - Jack, Philippa 
A1  - Boyle, David 
T1  - DNA microarrays for pathogen detection and characterisation
JF  - Microbiology Australia
JO  - Microbiol. Aust.
Y1  - 2006
VL  - 27
IS  - 2
SP  - 68
EP  - 69
KW  - 
UR  - https://doi.org/10.1071/MA06068 
N2  - DNA microarrays have three main potential diagnostic uses in clinical microbiology: detection of known pathogens, pathogen typing and novel pathogen discovery. Although DNA microarray platforms offer the ability to screen for a large number of agents in parallel, sensitivity is dependent on the ability to obtain adequate amounts of pathogen nucleic acids from collected samples. In general, high levels of sensitivity require a PCR amplification step using specific primer sets, subsequently reducing the overall scope of the microarray assay. At present, relatively high costs, restricted sample throughput capabilities and validation difficulties are also major factors limiting the implementation of DNA microarray assays in diagnostic microbiology laboratories. 
ER  -

