
%0 Journal Article
%A Lithgow, Trevor 
%T Compartmentation of cellular activities
%J Microbiology Australia
%D 2007/05/01
%V 28
%N 2
%P 64-66
%K 
%R https://doi.org/10.1071/MA07064
%U https://www.publish.csiro.au/paper/MA07064 
%X In the yeast Saccharomyces cerevisiae, almost one third of cellular function is concerned with maintaining the compartmentation of cellular activities. From classic studies in yeast genetics we have come to understand a great deal of the processes driving the delivery of proteins into these compartments and the metabolic advantages that this provides. With the publication of the yeast genome sequence, ?-omics? level studies began to provide further detail on the compartmentation of yeast cells. Very recent technological advances, including new applications in mass spectrometry, NMR, cryo-electron microscopy and the use of live-cell imaging have also been applied to yeast, because of the comparative analyses that can be done on yeast mutants. The mitochondrion is a complex compartment, carrying more than a thousand proteins that must be transported into and then distributed between, four sub-mitochondrial compartments. Essential molecular machinery in the outer and inner membranes, the intermembrane space and the matrix of mitochondria, drive protein transport, sorting and assembly. A glimpse of how S. cerevisiae and other microbes have provided understanding of cellular compartments is the aim of this review. 
