
TY  - JOUR
A1  - Kishi, Hisashi 
A1  - Okada, Toshiyuki 
A1  - Kawazu, Satoko 
A1  - Otsuka, Mariko 
A1  - Taya, Kazuyoshi 
A1  - Watanabe, Gen 
A1  - Sasamoto, Shuji 
T1  - Effects of passive immunization against oestradiol-17&#946; and inhibin on the secretion of gonadotrophin in the cyclic golden hamster (<emph type="2">Mesocricetus auratus</emph>)
JF  - Reproduction, Fertility and Development
JO  - Reprod. Fertil. Dev.
Y1  - 1997
VL  - 9
IS  - 4
SP  - 447
EP  - 454
KW  - FSH, LH, follicular development.
UR  - https://doi.org/10.1071/R96076 
N2  - To investigate the physiological importance of oestradiol-17b and inhibin in the regulation of gonadotrophin secretion in the cyclic golden hamster, females were passively immunized against two hormones. When 200 &#181;L antiserum against oestradiol-17&#946; (oestradiol-AS) was given on Day 3 (Day 1 = day of ovulation), the preovulatory gonadotrophin surge was completely blocked for 24 h and the length of the oestrous cycle was also prolonged for one day. In the group given 200&#181;L oestradiol-AS on Day 3, basal levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) increased slightly and superovulation (19&#183;6 &#177; 0&#183;8, mean &#177; s.e.m.) occurred. When 200 &#181;L antiserum against inhibin (inhibin-AS) was given at 1100 hours on Day 3, a dramatic increase in plasma FSH and a slight increase in LH were noted, resulting in superovulation (38&#183;2 &#177; 2&#183;6) on the expected Day 1. The present study indicates clearly that inhibin plays a major role in regulating the specific ovulation rate in the hamster through the control of FSH secretion. Present results also indicate that oestradiol-17&#946; suppresses basal LH secretion. Oestradiol-17&#946; may act as an indicator of the follicular maturation, and the high plasma concentration of oestradiol-17&#946; noted from Day 3 to Day 4 may play an important role in determining the timing of initiation of the preovulatory gonadotrophin surge. 
ER  -

