
%0 Journal Article
%A Ludwig, Tenneille E. 
%A Whiteaker, Shawn S. 
%A Carnahan, Kevin G. 
%A Tysseling, Kelly A. 
%A Mirando, Mark A. 
%T Control of endometrial phosphoinositide hydrolysis and prostaglandin F<emph tye="8">2&#945;</emph> a secretion in pigs
%J Reproduction, Fertility and Development
%D 1999/02/04
%V 10
%N 3
%P 249-254
%K oxytocin, vasopressin, endometrium, phosphoinositide, prostaglandin F2&#945; , pigs.
%R https://doi.org/10.1071/R97079
%U https://www.publish.csiro.au/paper/R97079 
%X This study examined the control of endometrial phosphoinositide (PI) hydrolysis and prostaglandin (PG) F2&#945; release by oxytocin (OT) and vasopressin in cyclic pigs on Day 15 post oestrus. In Expt 1, OT and arginine-vasopressin (AVP) increased endometrial PI hydrolysis (P&#60;0.01), but only OT stimulated (P&#60;0.01) PGF2&#945; secretion. In Expt 2, OT and lysine-vasopressin (LVP) increased PI hydrolysis (P&#60;0.01). No difference was detected between the 100 n and 200 n concentrations of OT or between the 100 n and 200 n concentrations of LVP. The increase in PI hydrolysis was greater (P&#60;0.05) for 100 n OT plus 100 n LVP than for the 100 or 200 n concentrations of OT or LVP alone. In Expt 3, OT (P&#60;0.01) and LVP increased (P&#60;0.01) PI hydrolysis. An OT antagonist abolished (P&#60;0.01) the OT-induced increase in PI hydrolysis, but did not significantly alter the LVP-induced increase. A type 2 VP antagonist completely inhibited (P&#60;0.01) the LVP-induced increase in PI hydrolysis, but only partially antagonized the stimulatory effect of OT (P&#60;0.01). These results are consistent with the proposal that OT acts through specific receptors to promote endometrial PGF2&#945; secretion in pigs. 
