
TY  - JOUR
A1  - Cann, C. H. 
A1  - Fairclough, R. J. 
A1  - Browne, C. A. 
A1  - Gow, C. B. 
T1  - Uterine luminal content of insulin-like growth factor (IGF)-I and endometrial expression of mRNA encoding IGF-binding proteins 1 and 2 during the oestrous cycle and early pregnancy in the ewe
JF  - Reproduction, Fertility and Development
JO  - Reprod. Fertil. Dev.
Y1  - 1998
VL  - 10
IS  - 2
SP  - 155
EP  - 163
KW  - 
UR  - https://doi.org/10.1071/R98017 
N2  - Cyclic (n= 30) and pregnant (n = 29) Merino ewes were examined (n = 3 to 5 at most time points) over Days 0&#8211;16 and 0&#8211;22 after oestrus, respectively. As IGFBP activity was detected in some plasma and ULF samples, all samples were subjected to acid-gel chromatography before assay for IGF-I. After oestrus, the overall means of both groups of ewes showed lower ULF IGF-I content (Days 3 and 12), lower plasma IGF-I concentrations (Days 3&#8211;16), higher endometrial expression of mRNA encoding IGFBP-1 (Days 12&#8211;16) and lower endometrial expression of mRNA encoding IGFBP-2 (Day 8). Between Days 0 and 16 after oestrus, the pregnant ewes had lower plasma IGF-I concentrations and higher endometrial expression of IGFBP-1 mRNA than did the cyclic ewes. The presence of IGF-I in the ULF throughout the oestrous cycle and early pregnancy suggests a role of IGF-I in early pregnancy, influencing both uterine growth and embryonic survival. The concomitant endometrial expression of mRNA encoding IGFBP-1 and IGFBP-2 suggests a role of these binding proteins in the regulation of IGF-I bioavailability in the uterine environment of the ewe. 
ER  -

