
TY  - JOUR
A1  - Gosden, Roger G. 
A1  - Faddy, Malcolm J. 
T1  - Biological bases of premature ovarian failure
JF  - Reproduction, Fertility and Development
JO  - Reprod. Fertil. Dev.
Y1  - 1998
VL  - 10
IS  - 1
SP  - 73
EP  - 78
KW  - 
UR  - https://doi.org/10.1071/R98043 
N2  - The ovary is endowed at birth with a fixed number of primordial follicles, which steadily dwindles throughout life as a result of atresia and recruitment towards ovulation. In addition to age, the number varies allometrically between species, larger and longer-lived animals tending to have more follicles initially and these disappear at a slower rate. A causal relationship between follicle depletion and menopause clearly exists, and there is a gradual acceleration of follicle wastage in the human ovary beginning more than a decade before the end of menstrual life. A mathematical model has provided confirmatory evidence of this relationship, and indicates that menopause is triggered by a threshold number of follicles which varies stochastically with a mean of 1100 
ER  -

