
TY  - JOUR
A1  - Salamonsen, Lois A. 
A1  - Nie, Guiying 
A1  - Dimitriadis, Eva 
A1  - Robb, Lorraine 
A1  - Findlay, Jock K. 
T1  - Genes involved in implantation
JF  - Reproduction, Fertility and Development
JO  - Reprod. Fertil. Dev.
Y1  - 2001
VL  - 13
IS  - 1
SP  - 41
EP  - 49
KW  - calbindin-D9k, interleukin-11, leukemia inhibitory factor, monoclonal non-specific suppressor factor &#946; , splicing factor SC35.
UR  - https://doi.org/10.1071/RD00046 
N2  - The endometrium is normally a hostile environment for an embryo, except for a short phase in each reproductive cycle known as the &#8216;window of receptivity&#8217;. The precise molecular events involved in this transformation are not well understood. Application of state-of-the-art techniques of the 1990s has identified some of the genes involved, which are reviewed here. Mice with a null mutation in either the gene for leukemia inhibitory factor or the interleukin-11 receptor &#945; chain are infertile, owing in both cases to a failure of embryo implantation. Both of these genes are expressed in the human endometrium with patterns suggesting a role in human fertility. The technique of RNA differential display has been applied to a comparison of the expression of genes at implantation sites v. inter-implantation sites in the mouse uterus on the first day of implantation, and has defined additional genes whose products may be important for this process. Among these are the calcium-binding protein D9K, the monoclonal non-specific suppressor factor &#946; , and the splicing factor SC35. The major challenge is to determine whether manipulation of such genes can increase or decrease endometrial receptivity in humans. 
ER  -

