
TY  - JOUR
A1  - Asakura, Hirobumi 
A1  - Nakai, Akihito 
A1  - Power, Gordon G. 
A1  - Araki, Tsutomu 
T1  - Short-term effects of different thermal conditions during uteroplacental ischaemia on fetal growth of Sprague-Dawley rats
JF  - Reproduction, Fertility and Development
JO  - Reprod. Fertil. Dev.
Y1  - 2002
VL  - 14
IS  - 6
SP  - 355
EP  - 361
KW  - hyperthermia, hypothermia, intrauterine fetal growth retardation, ischaemia&#8211;reperfusion injury, pregnancy.
UR  - https://doi.org/10.1071/RD01021 
N2  - The purpose of the present study was to investigate the short-term effect of various body temperatures on fetal growth during uteroplacental ischaemia. Under mild hyperthermia (n = 6), normothermia (n = 6) and hypothermia (n = 6), a 30-min period of ischaemia was induced in Sprague-Dawley rat dams by clamping the uterine arteries of one uterine horn at 17 days of gestation, leaving the other horn undisturbed. Three days later, the bodyweight of the pups, and the weights of the brains, livers and placentas were compared using the Mann&#8211;Whitney U-test. Fetal bodyweight, organ and placental weights were significantly reduced in the uterine horns subjected to ischaemia under the conditions of mild hyperthermia and normothermia (P &#60;0.05), but not with mild hypothermia, compared with the weights in undisturbed uterine horns. It was concluded that both mild hyperthermia and normothermia during ischaemia retard the growth of late-gestation rat pups, in contrast to the sparing effect of mild hypothermia. 
ER  -

