
TY  - JOUR
A1  - Yuan, Ma 
A1  - Wen-Xia, Zhou 
A1  - Jun-Ping, Cheng 
A1  - Yong-Xiang, Zhang 
T1  - <I>Erratum to</I>: Age-related changes in the oestrous cycle and reproductive hormones in senescence-accelerated mouse
JF  - Reproduction, Fertility and Development
JO  - Reprod. Fertil. Dev.
Y1  - 2009
VL  - 21
IS  - 4
SP  - 624
EP  - 624
KW  - &#946;-endorphin, luteinising hormone, oestradiol, substance P.
UR  - https://doi.org/10.1071/RD04099_ER 
N2  - To investigate age-related changes in the oestrous cycle and reproductive hormone levels in senescence-accelerated mouse (SAM), we examined these parameters in 3-, 5-, 7-, 9- and 11-month-old female SAM-prone/8 (SAMP8) and SAM-resistant/1 (SAMR1) strains. Levels of ²-endorphin (²-EP) and substance P (SP) in the hypothalamus were also measured. The oestrous cycle and dioestrus of 9-month-old SAMP8 mice were significantly prolonged compared with age-matched SAMR1 mice. Furthermore, the concentration of serum oestradiol was lower and the level of pituitary luteinising hormone was higher in SAMP8 mice compared with SAMR1 mice. This characterises the hypothalamus.pituitary.ovary (HPO) axis of the SAMP8 strain as hypergonadotropic.hypogonad. The levels of ²-EP and SP in the SAMP8 hypothalamus were lower than in the SAMR1 hypothalamus. These results indicate that the function of the HPO axis in SAMP8 mice declines early and this may be attributed, in part, to the decline in ²-EP and SP concentrations in the hypothalamus. 
ER  -

