
%0 Journal Article
%A Chu, Da-Peng 
%A Tian, Shi 
%A Sun, Da-Guang 
%A Hao, Chan-Juan 
%A Xia, Hong-Fei 
%A Ma, Xu 
%T <i>Corrigendum to</i>: Exposure to mono-n-butyl phthalate disrupts the development of preimplantation embryos
%J Reproduction, Fertility and Development
%D 2014/03/12
%V 26
%N 3
%P 491-491
%K 
%R https://doi.org/10.1071/RD12178_CO
%U https://www.publish.csiro.au/paper/RD12178_CO 
%X Dibutyl phthalate (DBP), a widely used phthalate, is known to cause many serious diseases, especially in the reproductive system. However, little is known about the effects of its metabolite, mono-n-butyl phthalate (MBP), on preimplantation embryo development. In the present study, we found that treatment of embryos with 10&#x2013;3M MBP impaired developmental competency, whereas exposure to 10&#x2013;4M MBP delayed the progression of preimplantation embryos to the blastocyst stage. Furthermore, reactive oxygen species (ROS) levels in embryos were significantly increased following treatment with 10&#x2013;3M MBP. In addition, 10&#x2013;3M MBP increased apoptosis via the release of cytochrome c, whereas immunofluorescent analysis revealed that exposure of preimplantation embryos to MBP concentration-dependently (10&#x2013;5, 10&#x2013;4 and 10&#x2013;3M) decreased DNA methylation. Together, the results indicate a possible relationship between MBP exposure and developmental failure in preimplantation embryos. 
