
%0 Journal Article
%A Almeida, Paula A. 
%A Bolton, Virginia N. 
%T Cytogenetic analysis of human preimplantation embryos following developmental arrest <emph type="2">in vitro</emph>
%J Reproduction, Fertility and Development
%D 1999/08/27
%V 10
%N 6
%P 505-513
%K chromosomal abnormalities, in vitro fertilization.
%R https://doi.org/10.1071/RD98040
%U https://www.publish.csiro.au/paper/RD98040 
%X The relationship between chromosomal abnormalities in the human preimplantation embryo and developmental arrest in vitro was investigated. Cytogenetic analysis of 171 embryos that had arrested between the pronucleate and the 8-cell stages demonstrated that the overall incidence of chromosomal abnormality among these embryos was 63.4%. Of the embryos that arrested at the pronucleate stage (n = 48), 47.9% were chromosomally abnormal, compared with 59.5% of those that arrested between the 2- and 4-cell stages (n = 50), and 82.8% of those arrested between the 5- and 8-cell stage (n = 73). The rate of abnormality in embryos with poor morphology (irregular shaped blastomeres and considerable extracellular fragmentation) was significantly higher (86.8%; n = 33) than those with good morphology (60%; n = 51; P&#60;0.005). These results suggest that there is an association between chromosomal abnormality, developmental arrest in vitro, and poor morphology. 
