
TY  - JOUR
A1  - Almeida, Paula A. 
A1  - Bolton, Virginia N. 
T1  - Cytogenetic analysis of human preimplantation embryos following developmental arrest <emph type="2">in vitro</emph>
JF  - Reproduction, Fertility and Development
JO  - Reprod. Fertil. Dev.
Y1  - 1999
VL  - 10
IS  - 6
SP  - 505
EP  - 513
KW  - chromosomal abnormalities, in vitro fertilization.
UR  - https://doi.org/10.1071/RD98040 
N2  - The relationship between chromosomal abnormalities in the human preimplantation embryo and developmental arrest in vitro was investigated. Cytogenetic analysis of 171 embryos that had arrested between the pronucleate and the 8-cell stages demonstrated that the overall incidence of chromosomal abnormality among these embryos was 63.4%. Of the embryos that arrested at the pronucleate stage (n = 48), 47.9% were chromosomally abnormal, compared with 59.5% of those that arrested between the 2- and 4-cell stages (n = 50), and 82.8% of those arrested between the 5- and 8-cell stage (n = 73). The rate of abnormality in embryos with poor morphology (irregular shaped blastomeres and considerable extracellular fragmentation) was significantly higher (86.8%; n = 33) than those with good morphology (60%; n = 51; P&#60;0.005). These results suggest that there is an association between chromosomal abnormality, developmental arrest in vitro, and poor morphology. 
ER  -

