
%0 Journal Article
%A Kono, Tomohiro 
%T Influence of epigenetic changes during oocyte growth on nuclear reprogramming after nuclear transfer
%J Reproduction, Fertility and Development
%D 1999/09/17
%V 10
%N 8
%P 593-598
%K 
%R https://doi.org/10.1071/RD98056
%U https://www.publish.csiro.au/paper/RD98056 
%X Genomic imprinting is the epigenetic mechanism that distinguishes whether the loci that are inherited from the maternal or paternal genome lead to parent-specific gene expression. The mechanism also regulates development in mammalian embryos. Genomic imprinting is established after implantation according to the specific markers that are imposed on the genome during gametogenesis; the allele-specific gene expression is then maintained throughout embryogenesis. The genomic imprinting markers are erased and renewed on an own-sex basis only in cells that differentiate into germline cells. This report shows that the epigenetic modifications that occur during oogenesis perform the crucial function of establishing the allele-specific expression of imprinted genes, and also suggests that the epigenetic DNA modification is related to the reprogramming and aberrant development seen in manipulated embryos. 
