
%0 Journal Article
%A Shemesh, M 
%T Production and regulation of progesterone in bovine corpus luteum and placenta in mid and late gestation: a personal review
%J Reproduction, Fertility and Development
%D 1990/04/01
%V 2
%N 2
%P 129-135
%K 
%R https://doi.org/10.1071/RD9900129
%U https://www.publish.csiro.au/paper/RD9900129 
%X In late pregnancy the secretory activity of the corpus luteum of the cow is markedly diminished. This reduced secretion is due to a decline in the number of viable luteal cells as well as reduction in the secretory activity and responsiveness of the cells to trophic agents. The principal extra-ovarian source of progesterone in late gestation appears to be the placenta, especially the fetal cotyledon, which was shown to produce progesterone throughout gestation. Uniquely, this progesterone biosynthesis is cyclic-nucleotide independent, but Ca2+ dependent. It therefore appears that the Ca2(+)-second messenger and protein kinase C systems are responsible for regulation of sterol biosynthesis in the cow placenta. 
