
TY  - JOUR
A1  - Shemesh, M 
T1  - Production and regulation of progesterone in bovine corpus luteum and placenta in mid and late gestation: a personal review
JF  - Reproduction, Fertility and Development
JO  - Reprod. Fertil. Dev.
Y1  - 1990
VL  - 2
IS  - 2
SP  - 129
EP  - 135
KW  - 
UR  - https://doi.org/10.1071/RD9900129 
N2  - In late pregnancy the secretory activity of the corpus luteum of the cow is markedly diminished. This reduced secretion is due to a decline in the number of viable luteal cells as well as reduction in the secretory activity and responsiveness of the cells to trophic agents. The principal extra-ovarian source of progesterone in late gestation appears to be the placenta, especially the fetal cotyledon, which was shown to produce progesterone throughout gestation. Uniquely, this progesterone biosynthesis is cyclic-nucleotide independent, but Ca2+ dependent. It therefore appears that the Ca2(+)-second messenger and protein kinase C systems are responsible for regulation of sterol biosynthesis in the cow placenta. 
ER  -

