
%0 Journal Article
%A Krishna, BR 
%A King, RG 
%A Gu, W 
%A Brennecke, SP 
%T Effect of indomethacin on materno-fetal amino acid transfer in the dual-perfused human placental cotyledon
%J Reproduction, Fertility and Development
%D 1990/10/01
%V 2
%N 5
%P 597-602
%K 
%R https://doi.org/10.1071/RD9900597
%U https://www.publish.csiro.au/paper/RD9900597 
%X Indomethacin (1, 10 and 100 mumol L-1) was incrementally infused (8 min for each concentration) into the maternal and fetal circulations of dual-perfused human placental lobules, and measurements were made of materno-fetal amino acid transfer (using the non-metabolizable amino acid alpha-aminoisobutyric acid, or AIB) and fetal effluent perfusate prostaglandin (PG) E levels. No significant changes in AIB transfer compared with controls were observed at any of the doses of indomethacin infused. There was, however, a significant dose-dependent reduction compared with controls in PGE in the fetal circulation with the infusion of indomethacin. 
