
%0 Journal Article
%A Sheldrick, EL 
%T Oxytocin delays oestradiol-induced luteolysis but does not affect oestradiol-induced luteinizing hormone secretion in the ewe
%J Reproduction, Fertility and Development
%D 1992/10/01
%V 4
%N 5
%P 593-599
%K 
%R https://doi.org/10.1071/RD9920593
%U https://www.publish.csiro.au/paper/RD9920593 
%X Circulating concentrations of progesterone, the prostaglandin F2 alpha (PGF2 alpha), metabolite 13,14-dihydro-15-keto PGF2 alpha (DHKF2 alpha) and luteinizing hormone (LH) have been measured in cyclic ewes receiving a continuous infusion of oxytocin, in order to investigate the effect of maintained concentrations of circulating oxytocin on the luteolytic action of oestradiol-17 beta. Oxytocin (3 nmol h-1 intravenously) was given from Day 7 until Day 17 after oestrus with oestradiol-17 beta (2.76 mumol, intramuscularly in sesame oil, 0.5 mL-1) administered on Days 9 and 10. Control ewes, given a continuous infusion of saline (154 mmol L-1, 3 mL-1 h-1) and sesame oil on Days 9 and 10, underwent luteal regression at the expected time, with mean concentrations of plasma progesterone falling to below 1.5 nmol L-1 on Day 16 (0900 hours). Mean plasma progesterone concentrations fell to less than 1.5 nmol L-1 on Day 13 (0900 hours) in ewes receiving saline and oestradiol-17 beta. Oxytocin infusion delayed luteolysis in all treated ewes; those receiving oxytocin infusion and sesame oil failed to undergo luteal regression during the period studied and in animals receiving oxytocin and oestradiol-17 beta, luteolysis was significantly delayed when compared to ewes treated with saline and oestradiol with progesterone concentrations falling to < 1.5 nmol L-1 on Days 14 (n = 1 ewe), 15 (n = 1 ewe), 16 (n = 2 ewes) and > 17 (n = 2 ewes) (P < 0.05). 
