
%0 Journal Article
%A Zakar, T 
%A Olson, DM 
%T Studies on glucocorticoid hormone actions in the regulation of human amnion PGHS
%J Reproduction, Fertility and Development
%D 1995/06/01
%V 7
%N 3
%P 517-520
%K 
%R https://doi.org/10.1071/RD9950517
%U https://www.publish.csiro.au/paper/RD9950517 
%X The human amnion is an excellent model in which to study the regulation of the expression of prostaglandin endoperoxide H synthase-2 (PGHS-2) mRNA by glucocorticoids, as glucocorticoids can both stimulate and inhibit PGHS activity and can have their stimulatory effect reversed to an inhibitory one. Our studies suggest the presence of a glucocorticoid-induced inhibitory protein which affects the post-transcriptional activity of PGHS-2 mRNA. Glucocorticoid-induced expression of PGHS-2 mRNA may be dependent on protein phosphorylation. 
