A diverse English keyword search reveals the value of scriptaid treatment for porcine embryo development following somatic cell nuclear transfer
Wei Li A , Hui Zheng A * , Yali Yang A , Hong Xu A and Zhenhua Guo
B *
+ Author Affiliations
- Author Affiliations
A Northeast Agricultural University, College of Arts and Sciences, No. 600 Changjiang Road, Xiangfang District, Harbin 150030, P. R. China.
B Heilongjiang Academy of Agricultural Sciences, Animal Husbandry Research Institute, No. 368 Xuefu Road, Harbin 150086, P. R. China.
Reproduction, Fertility and Development 34(11) 798-803 https://doi.org/10.1071/RD22025
Published online: 18 May 2022
© 2022 The Author(s) (or their employer(s)). Published by CSIRO Publishing
Abstract
Context: Incomplete epigenetic reprogramming of histone deacetylation (HDAC) is one of the main reasons for the low efficiency of somatic cell nuclear transfer (SCNT). Scriptaid is a synthetic HDAC inhibitor (HDACi) that may improve the efficiency of porcine SCNT.
Aims: This study aimed to determine whether scriptaid increases the number of blastocyst cells or the cleavage rate.
Methods: We conducted a meta-analysis of the pertinent literature published over the past decade.
Key results: A total of 73 relevant papers were retrieved using a diverse English keyword search, and 11 articles were used for the meta-analysis. Scriptaid was positively correlated with blastocyst rate but had no effect on cleavage rate or blastocyst cell number. A subgroup analysis of blastocyst cell number showed that the staining method was the source of the heterogeneity.
Conclusions: In SCNT embryos, scriptaid treatment after activation can promote embryonic development, but there may be adverse effects on early development.
Implications: HDACi research should focus on SCNT birth efficiency.
Keywords: blastocyst, cloning, embryo, HDACi, in vitro maturation, meta-analysis, SCNT, scriptaid.
References
Al-Ghadi, MQ, Alhimaidi, AR, Iwamoto, D, AL-Mutary, MG, Ammari, AA, Saeki, KO, and Aleissa, MS (2020). The in vitro development of cloned sheep embryos treated with scriptaid and trichostatin (A). Saudi Journal of Biological Sciences 27, 2280–2286.| The in vitro development of cloned sheep embryos treated with scriptaid and trichostatin (A).Crossref | GoogleScholarGoogle Scholar | 32884408PubMed |
Ao, Z, Chen, X, Wu, ZF, and Li, ZC (2020). Progress on abnormal development of cloned pigs generated by somatic cell transfer nuclear. Yi Chuan 42, 993–1003.
| Progress on abnormal development of cloned pigs generated by somatic cell transfer nuclear.Crossref | GoogleScholarGoogle Scholar | 33229324PubMed |
Cao, Z, Hong, R, Ding, B, Zuo, X, Li, H, Ding, J, Li, Y, Huang, W, and Zhang, Y (2017). TSA and BIX-01294 induced normal DNA and histone methylation and increased protein expression in porcine somatic cell nuclear transfer embryos. PLoS ONE 12, e0169092.
| TSA and BIX-01294 induced normal DNA and histone methylation and increased protein expression in porcine somatic cell nuclear transfer embryos.Crossref | GoogleScholarGoogle Scholar | 28114389PubMed |
Fang, X, Xia, W, Cao, H, Guo, Y, Wang, H, Zhang, X, Wan, P, Liu, C, Wei, Q, Sun, S, Tian, S, Li, J, and Wang, Z (2020). Effect of supplemetation of zebularine and scriptaid on efficiency of in vitro developmental competence of ovine somatic cell nuclear transferred embryos. Animal Biotechnology 31, 155–163.
| Effect of supplemetation of zebularine and scriptaid on efficiency of in vitro developmental competence of ovine somatic cell nuclear transferred embryos.Crossref | GoogleScholarGoogle Scholar | 30734624PubMed |
Guo, Z, Lv, L, Liu, D, and Fu, B (2018). Effects of trichostatin A on pig SCNT blastocyst formation rate and cell number: a meta-analysis. Research in Veterinary Science 117, 161–166.
| Effects of trichostatin A on pig SCNT blastocyst formation rate and cell number: a meta-analysis.Crossref | GoogleScholarGoogle Scholar | 29277014PubMed |
Huan, Y, Wang, H, Wu, Z, Zhang, J, Zhu, J, Liu, Z, and He, H (2015). Epigenetic modification of cloned embryos improves Nanog reprogramming in pigs. Cellular Reprogramming 17, 191–198.
| Epigenetic modification of cloned embryos improves Nanog reprogramming in pigs.Crossref | GoogleScholarGoogle Scholar | 26053519PubMed |
Huang, J, Zhang, H, Yao, J, Qin, G, Wang, F, Wang, X, Luo, A, Zheng, Q, Cao, C, and Zhao, J (2016). BIX-01294 increases pig cloning efficiency by improving epigenetic reprogramming of somatic cell nuclei. Reproduction 151, 39–49.
| BIX-01294 increases pig cloning efficiency by improving epigenetic reprogramming of somatic cell nuclei.Crossref | GoogleScholarGoogle Scholar | 26604326PubMed |
Keen, JC, Yan, L, Mack, KM, Pettit, C, Smith, D, Sharma, D, and Davidson, NE (2003). A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor α (ER) in ER negative human breast cancer cells in combination with 5-aza 2′-deoxycytidine. Breast Cancer Research and Treatment 81, 177–186.
| A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor α (ER) in ER negative human breast cancer cells in combination with 5-aza 2′-deoxycytidine.Crossref | GoogleScholarGoogle Scholar | 14620913PubMed |
Lee, D-K, Park, C-H, Choi, K-H, Jeong, Y-I, Uh, K-J, Hwang, J-Y, Lee, S-G, and Lee, C-K (2016). Aggregation of cloned embryos in empty zona pellucida improves derivation efficiency of pig ES-like cells. Zygote 24, 909–917.
| Aggregation of cloned embryos in empty zona pellucida improves derivation efficiency of pig ES-like cells.Crossref | GoogleScholarGoogle Scholar | 27692031PubMed |
Li, W, Xu, H, Yin, Y, Shen, W, Sun, Q-Y, and Zhao, M (2019). In vitro production of canine blastocysts. Theriogenology 135, 164–168.
| In vitro production of canine blastocysts.Crossref | GoogleScholarGoogle Scholar | 31216507PubMed |
Liu, Z, Xiang, G, Xu, K, Che, J, Xu, C, Li, K, Wang, B, and Mu, Y (2020). Transcriptome analyses reveal differential transcriptional profiles in early- and late-dividing porcine somatic cell nuclear transfer embryos. Genes 11, 1499.
| Transcriptome analyses reveal differential transcriptional profiles in early- and late-dividing porcine somatic cell nuclear transfer embryos.Crossref | GoogleScholarGoogle Scholar |
Mazur, U, Lepiarczyk, E, Janikiewicz, P, and Bossowska, A (2021). Somatostatin immunoreactivity within the urinary bladder nerve fibers and paracervical ganglion urinary bladder projecting neurons in the female pig. Journal of Chemical Neuroanatomy 117, 102007.
| Somatostatin immunoreactivity within the urinary bladder nerve fibers and paracervical ganglion urinary bladder projecting neurons in the female pig.Crossref | GoogleScholarGoogle Scholar | 34314850PubMed |
Ongaratto, FL, Rodriguez-Villamil, P, Bertolini, M, and Carlson, DF (2020). Influence of oocyte selection, activation with a zinc chelator and inhibition of histone deacetylases on cloned porcine embryo and chemically activated oocytes development. Zygote 28, 286–290.
| Influence of oocyte selection, activation with a zinc chelator and inhibition of histone deacetylases on cloned porcine embryo and chemically activated oocytes development.Crossref | GoogleScholarGoogle Scholar | 32285760PubMed |
Park, C-H, Jeong, YH, Jeong, Y-I, Lee, S-Y, Jeong, Y-W, Shin, T, Kim, N-H, Jeung, E-B, Hyun, S-H, Lee, C-K, Lee, E, and Hwang, WS (2012a). X-linked gene transcription patterns in female and male in vivo, in vitro and cloned porcine individual blastocysts. PLoS ONE 7, e51398.
| X-linked gene transcription patterns in female and male in vivo, in vitro and cloned porcine individual blastocysts.Crossref | GoogleScholarGoogle Scholar | 23236494PubMed |
Park, S-J, Park, H-J, Koo, O-J, Choi, W-J, Moon, J-h, Kwon, D-K, Kang, J-T, Kim, S, Choi, J-Y, Jang, G, and Lee, B-C (2012b). Oxamflatin improves developmental competence of porcine somatic cell nuclear transfer embryos. Cellular Reprogramming 14, 398–406.
| Oxamflatin improves developmental competence of porcine somatic cell nuclear transfer embryos.Crossref | GoogleScholarGoogle Scholar | 23013534PubMed |
Rissi, VB, Glanzner, WG, Mujica, LKS, Antoniazzi, AQ, Gonçalves, PBD, and Bordignon, V (2016). Effect of cell cycle interactions and inhibition of histone deacetylases on development of porcine embryos produced by nuclear transfer. Cellular Reprogramming 18, 8–16.
| Effect of cell cycle interactions and inhibition of histone deacetylases on development of porcine embryos produced by nuclear transfer.Crossref | GoogleScholarGoogle Scholar | 27281695PubMed |
Rissi, VB, Glanzner, WG, de Macedo, MP, Mujica, LKS, Campagnolo, K, Gutierrez, K, Bridi, A, Baldassarre, H, Gonçalves, PBD, and Bordignon, V (2019). Inhibition of RNA synthesis during scriptaid exposure enhances gene reprogramming in SCNT embryos. Reproduction 157, 123–133.
| Inhibition of RNA synthesis during scriptaid exposure enhances gene reprogramming in SCNT embryos.Crossref | GoogleScholarGoogle Scholar | 30444719PubMed |
Samiec, M, and Skrzyszowska, M (2018a). Can reprogramming of overall epigenetic memory and specific parental genomic imprinting memory within donor cell-inherited nuclear genome be a major hindrance for the somatic cell cloning of mammals? – a review. Annals of Animal Science 18, 623–638.
| Can reprogramming of overall epigenetic memory and specific parental genomic imprinting memory within donor cell-inherited nuclear genome be a major hindrance for the somatic cell cloning of mammals? – a review.Crossref | GoogleScholarGoogle Scholar |
Samiec, M, and Skrzyszowska, M (2018b). Intrinsic and extrinsic molecular determinants or modulators for epigenetic remodeling and reprogramming of somatic cell-derived genome in mammalian nuclear-transferred oocytes and resultant embryos. Polish Journal of Veterinary Sciences 21, 217–227.
| Intrinsic and extrinsic molecular determinants or modulators for epigenetic remodeling and reprogramming of somatic cell-derived genome in mammalian nuclear-transferred oocytes and resultant embryos.Crossref | GoogleScholarGoogle Scholar | 29624006PubMed |
Samiec, M, and Skrzyszowska, M (2021). Extranuclear inheritance of mitochondrial genome and epigenetic reprogrammability of chromosomal telomeres in somatic cell cloning of mammals. International Journal of Molecular Sciences 22, 3099.
| Extranuclear inheritance of mitochondrial genome and epigenetic reprogrammability of chromosomal telomeres in somatic cell cloning of mammals.Crossref | GoogleScholarGoogle Scholar | 33803567PubMed |
Samiec, M, Romanek, J, Lipiński, D, and Opiela, J (2019). Expression of pluripotency-related genes is highly dependent on trichostatin A-assisted epigenomic modulation of porcine mesenchymal stem cells analysed for apoptosis and subsequently used for generating cloned embryos. Animal Science Journal 90, 1127–1141.
| Expression of pluripotency-related genes is highly dependent on trichostatin A-assisted epigenomic modulation of porcine mesenchymal stem cells analysed for apoptosis and subsequently used for generating cloned embryos.Crossref | GoogleScholarGoogle Scholar | 31298467PubMed |
Skrzyszowska, M, and Samiec, M (2020). Enhancement of in vitro developmental outcome of cloned goat embryos after epigenetic modulation of somatic cell-inherited nuclear genome with trichostatin A. Annals of Animal Science 20, 97–108.
| Enhancement of in vitro developmental outcome of cloned goat embryos after epigenetic modulation of somatic cell-inherited nuclear genome with trichostatin A.Crossref | GoogleScholarGoogle Scholar |
Su, X, Gao, G, Wang, S, Su, G, Zheng, Z, Zhang, J, Han, L, Ling, Y, Wang, X, Li, G, and Zhang, L (2019). CircRNA expression profile of bovine placentas in late gestation with aberrant SCNT fetus. Journal of Clinical Laboratory Analysis 33, e22918.
| CircRNA expression profile of bovine placentas in late gestation with aberrant SCNT fetus.Crossref | GoogleScholarGoogle Scholar | 31131498PubMed |
Sun, H, Lu, F, Zhu, P, Liu, X, Tian, M, Luo, C, Ruan, Q, Ruan, Z, Liu, Q, Jiang, J, Wei, Y, and Shi, D (2015). Effects of scriptaid on the histone acetylation, DNA methylation and development of buffalo somatic cell nuclear transfer embryos. Cellular Reprogramming 17, 404–414.
| Effects of scriptaid on the histone acetylation, DNA methylation and development of buffalo somatic cell nuclear transfer embryos.Crossref | GoogleScholarGoogle Scholar | 26035741PubMed |
Wang, G, Jiang, X, Pu, H, Zhang, W, An, C, Hu, X, Liou, AK-F, Leak, RK, Gao, Y, and Chen, J (2013). Scriptaid, a novel histone deacetylase inhibitor, protects against traumatic brain injury via modulation of PTEN and AKT pathway: scriptaid protects against TBI via AKT. Neurotherapeutics 10, 124–142.
| Scriptaid, a novel histone deacetylase inhibitor, protects against traumatic brain injury via modulation of PTEN and AKT pathway: scriptaid protects against TBI via AKT.Crossref | GoogleScholarGoogle Scholar | 23132328PubMed |
Wang, Y, Liu, Q, Kang, J, Zhang, Y, and Quan, F (2020). Overexpression of PGC7 in donor cells maintains the DNA methylation status of imprinted genes in goat embryos derived from somatic cell nuclear transfer technology. Theriogenology 151, 86–94.
| Overexpression of PGC7 in donor cells maintains the DNA methylation status of imprinted genes in goat embryos derived from somatic cell nuclear transfer technology.Crossref | GoogleScholarGoogle Scholar | 32344274PubMed |
Wen, B-Q, Li, J, Li, J-J, Tian, S-J, Sun, S-C, Qi, X, Cai, W-T, and Chang, Q-L (2014). The histone deacetylase inhibitor scriptaid improves in vitro developmental competence of ovine somatic cell nuclear transferred embryos. Theriogenology 81, 332–339.
| The histone deacetylase inhibitor scriptaid improves in vitro developmental competence of ovine somatic cell nuclear transferred embryos.Crossref | GoogleScholarGoogle Scholar | 24182741PubMed |
Whitworth, KM, Mao, J, Lee, K, Spollen, WG, Samuel, MS, Walters, EM, Spate, LD, and Prather, RS (2015). Transcriptome analysis of pig in vivo, in vitro-fertilized, and nuclear transfer blastocyst-stage embryos treated with histone deacetylase inhibitors postfusion and activation reveals changes in the lysosomal pathway. Cellular Reprogramming 17, 243–258.
| Transcriptome analysis of pig in vivo, in vitro-fertilized, and nuclear transfer blastocyst-stage embryos treated with histone deacetylase inhibitors postfusion and activation reveals changes in the lysosomal pathway.Crossref | GoogleScholarGoogle Scholar | 26731590PubMed |
Wiater, J, Samiec, M, Skrzyszowska, M, and Lipiński, D (2021). Trichostatin A-assisted epigenomic modulation affects the expression profiles of not only recombinant human α1,2-fucosyltransferase and α-galactosidase A enzymes but also Galα1→3Gal epitopes in porcine bi-transgenic adult cutaneous fibroblast cells. International Journal of Molecular Sciences 22, 1386.
| Trichostatin A-assisted epigenomic modulation affects the expression profiles of not only recombinant human α1,2-fucosyltransferase and α-galactosidase A enzymes but also Galα1→3Gal epitopes in porcine bi-transgenic adult cutaneous fibroblast cells.Crossref | GoogleScholarGoogle Scholar | 33573215PubMed |
Xiong, X, Lan, D, Li, J, Zhong, J, Zi, X, Ma, L, and Wang, Y (2013). Zebularine and scriptaid significantly improve epigenetic reprogramming of yak fibroblasts and cloning efficiency. Cellular Reprogramming 15, 293–300.
| Zebularine and scriptaid significantly improve epigenetic reprogramming of yak fibroblasts and cloning efficiency.Crossref | GoogleScholarGoogle Scholar | 23790013PubMed |
Xu, W, Li, Z, Yu, B, He, X, Shi, J, Zhou, R, Liu, D, and Wu, Z (2013). Effects of DNMT1 and HDAC inhibitors on gene-specific methylation reprogramming during porcine somatic cell nuclear transfer. PLoS ONE 8, e64705.
| Effects of DNMT1 and HDAC inhibitors on gene-specific methylation reprogramming during porcine somatic cell nuclear transfer.Crossref | GoogleScholarGoogle Scholar | 23741375PubMed |
Zhang, L, Huang, Y, Wu, Y, Si, J, Huang, Y, Jiang, Q, Lan, G, Guo, Y, and Jiang, H (2017). Scriptaid upregulates expression of development-related genes, inhibits apoptosis, and improves the development of somatic cell nuclear transfer mini-pig embryos. Cellular Reprogramming 19, 19–26.
| Scriptaid upregulates expression of development-related genes, inhibits apoptosis, and improves the development of somatic cell nuclear transfer mini-pig embryos.Crossref | GoogleScholarGoogle Scholar | 28055234PubMed |
Zhao, J, Ross, JW, Hao, Y, Spate, LD, Walters, EM, Samuel, MS, Rieke, A, Murphy, CN, and Prather, RS (2009). Significant improvement in cloning efficiency of an inbred miniature pig by histone deacetylase inhibitor treatment after somatic cell nuclear transfer. Biology of Reproduction 81, 525–530.
| Significant improvement in cloning efficiency of an inbred miniature pig by histone deacetylase inhibitor treatment after somatic cell nuclear transfer.Crossref | GoogleScholarGoogle Scholar | 19386991PubMed |
Zhao, J, Hao, Y, Ross, JW, Spate, LD, Walters, EM, Samuel, MS, Rieke, A, Murphy, CN, and Prather, RS (2010). Histone deacetylase inhibitors improve in vitro and in vivo developmental competence of somatic cell nuclear transfer porcine embryos. Cellular Reprogramming 12, 75–83.
| Histone deacetylase inhibitors improve in vitro and in vivo developmental competence of somatic cell nuclear transfer porcine embryos.Crossref | GoogleScholarGoogle Scholar | 20132015PubMed |
Zhu, X, Nie, J, Quan, S, Xu, H, Yang, X, Lu, Y, Lu, K, and Lu, S (2016). In vitro production of cloned and transgenically cloned embryos from Guangxi Huanjiang Xiang pig. In Vitro Cellular & Developmental Biology - Animal 52, 137–143.
| In vitro production of cloned and transgenically cloned embryos from Guangxi Huanjiang Xiang pig.Crossref | GoogleScholarGoogle Scholar |
