Reproductive biology research down under: highlights from the Australian and New Zealand Annual Meeting of the Society for Reproductive Biology, 2021
Jessica E. M. Dunleavy
A * , Doan Thao Dinh B , Caitlin E. Filby C D , Ella Green E , Pierre Hofstee F , Taylor Pini G , Nicola Rivers D , David A. Skerrett-Byrne H I , Rukmali Wijayarathna J K , Yasmyn E. Winstanley B , Wei Zhou L M and Dulama Richani N
+ Author Affiliations
- Author Affiliations
A School of BioSciences, Faculty of Science, The University of Melbourne, Parkville, Vic. 3010, Australia.
B Robinson Research Institute, School of Biomedicine, Faculty of Health Sciences, The University of Adelaide, Adelaide, SA 5006, Australia.
C The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Vic. 3168, Australia.
D Department of Obstetrics and Gynaecology, School of Clinical Sciences, Monash University, Clayton, Vic. 3168, Australia.
E Robinson Research Institute and Adelaide Medical School, The University of Adelaide, Adelaide, SA 5006, Australia.
F Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia.
G School of Veterinary Science, The University of Queensland, Gatton, Qld 4343, Australia.
H School of Environmental and Life Sciences, College of Engineering, Science and Environment, The University of Newcastle, Callaghan, NSW 2308, Australia.
I Infertility and Reproduction Research Program, Hunter Medical Research Institute, New Lambton, NSW 2305, Australia.
J Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, Vic. 3168, Australia.
K Department of Molecular and Translational Sciences, School of Clinical Sciences, Monash University, Clayton, Vic. 3800, Australia.
L Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, Vic. 3010, Australia.
M Gynaecology Research Centre, Royal Women’s Hospital, Parkville, Vic. 3052, Australia.
N Fertility & Research Centre, School of Women’s and Children’s Health, University of New South Wales, Sydney, NSW 2031, Australia.
Reproduction, Fertility and Development 34(13) 855-866 https://doi.org/10.1071/RD22115
Published online: 15 July 2022
© 2022 The Author(s) (or their employer(s)). Published by CSIRO Publishing. This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND)
Abstract
Against the backdrop of a global pandemic, the Society for Reproductive Biology (SRB) 2021 meeting reunited the Australian and New Zealand reproductive research community for the first time since 2019 and was the first virtual SRB meeting. Despite the recent global research disruptions, the conference revealed significant advancements in reproductive research, the importance of which span human health, agriculture, and conservation. A core theme was novel technologies, including the use of medical microrobots for therapeutic and sperm delivery, diagnostic hyperspectral imaging, and hydrogel condoms with potential beyond contraception. The importance of challenging the contraceptive status quo was further highlighted with innovations in gene therapies, non-hormonal female contraceptives, epigenetic semen analysis, and in applying evolutionary theory to suppress pest population reproduction. How best to support pregnancies, particularly in the context of global trends of increasing maternal age, was also discussed, with several promising therapies for improved outcomes in assisted reproductive technology, pre-eclampsia, and pre-term birth prevention. The unique insights gained via non-model species was another key focus and presented research emphasised the importance of studying diverse systems to understand fundamental aspects of reproductive biology and evolution. Finally, the meeting highlighted how to effectively translate reproductive research into policy and industry practice.
Keywords: assisted reproduction, contraception, embryo, medical microrobots, oocyte, reproductive ageing, seminal plasma, Society for Reproductive Biology.
References
Agrahari, V, Agrahari, V, Chou, M-L, Chew, CH, Noll, J, and Burnouf, T (2020). Intelligent micro-/nanorobots as drug and cell carrier devices for biomedical therapeutic advancement: Promising development opportunities and translational challenges. Biomaterials 260, 120163.| Intelligent micro-/nanorobots as drug and cell carrier devices for biomedical therapeutic advancement: Promising development opportunities and translational challenges.Crossref | GoogleScholarGoogle Scholar | 32882512PubMed |
Akison, LK, Alvino, ER, Dunning, KR, Robker, RL, and Russell, DL (2012). Transient invasive migration in mouse cumulus oocyte complexes induced at ovulation by luteinizing hormone. Biology of Reproduction 86, 125.
| Transient invasive migration in mouse cumulus oocyte complexes induced at ovulation by luteinizing hormone.Crossref | GoogleScholarGoogle Scholar | 22238281PubMed |
Astolfi, P, and Zonta, LA (1999). Risks of preterm delivery and association with maternal age, birth order, and fetal gender. Human Reproduction 14, 2891–2894.
| Risks of preterm delivery and association with maternal age, birth order, and fetal gender.Crossref | GoogleScholarGoogle Scholar | 10548643PubMed |
Australian Institute of Health and Welfare (2021) Australia’s mothers and babies. Report No. PER 101. (Australian Institute of Health and Welfare: Canberra, Australia). Available at https://www.aihw.gov.au/reports/mothers-babies/australias-mothers-babies
Aziz, A, Holthof, J, Meyer, S, Schmidt, OG, and Medina-Sánchez, M (2021). Dual ultrasound and photoacoustic tracking of magnetically driven micromotors: from in vitro to in vivo. Advanced Healthcare Materials 10, 2101077.
| Dual ultrasound and photoacoustic tracking of magnetically driven micromotors: from in vitro to in vivo.Crossref | GoogleScholarGoogle Scholar |
Bearak, J, Popinchalk, A, Ganatra, B, Moller, A-B, Tunçalp, Ö, Beavin, C, Kwok, L, and Alkema, L (2020). Unintended pregnancy and abortion by income, region, and the legal status of abortion: estimates from a comprehensive model for 1990–2019. The Lancet Global Health 8, e1152–e1161.
| Unintended pregnancy and abortion by income, region, and the legal status of abortion: estimates from a comprehensive model for 1990–2019.Crossref | GoogleScholarGoogle Scholar | 32710833PubMed |
Binder, NK, Brownfoot, FC, Beard, S, Cannon, P, Nguyen, TV, Tong, S, Kaitu’u-Lino, TJ, and Hannan, NJ (2020). Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia. Pregnancy Hypertension 22, 86–92.
| Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia.Crossref | GoogleScholarGoogle Scholar | 32758704PubMed |
Binder, NK, MacDonald, TM, Beard, SA, de Alwis, N, Tong, S, Kaitu’u-Lino, TJ, and Hannan, NJ (2021). Pre-clinical investigation of cardioprotective beta-blockers as a therapeutic strategy for preeclampsia. Journal of Clinical Medicine 10, 3384.
| Pre-clinical investigation of cardioprotective beta-blockers as a therapeutic strategy for preeclampsia.Crossref | GoogleScholarGoogle Scholar | 34362171PubMed |
Bolton, H, Graham, SJL, Van der Aa, N, Kumar, P, Theunis, K, Fernandez Gallardo, E, Voet, T, and Zernicka-Goetz, M (2016). Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential. Nature Communications 7, 11165.
| Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential.Crossref | GoogleScholarGoogle Scholar | 27021558PubMed |
Bouzaglou, A, Aubenas, I, Abbou, H, Rouanet, S, Carbonnel, M, Pirtea, P, and Ayoubi, JMB (2020). Pregnancy at 40 years old and above: obstetrical, fetal, and neonatal outcomes. Is age an independent risk factor for those complications? Frontiers in Medicine 7, 208.
| Pregnancy at 40 years old and above: obstetrical, fetal, and neonatal outcomes. Is age an independent risk factor for those complications?Crossref | GoogleScholarGoogle Scholar | 32537454PubMed |
Care, AS, Bourque, SL, Morton, JS, Hjartarson, EP, Robertson, SA, and Davidge, ST (2018). Reduction in regulatory T cells in early pregnancy causes uterine artery dysfunction in mice. Hypertension 72, 177–187.
| Reduction in regulatory T cells in early pregnancy causes uterine artery dysfunction in mice.Crossref | GoogleScholarGoogle Scholar | 29785960PubMed |
Carlson, SE, Colombo, J, Gajewski, BJ, Gustafson, KM, Mundy, D, Yeast, J, Georgieff, MK, Markley, LA, Kerling, EH, and Shaddy, DJ (2013). DHA supplementation and pregnancy outcomes. The American Journal of Clinical Nutrition 97, 808–815.
| DHA supplementation and pregnancy outcomes.Crossref | GoogleScholarGoogle Scholar | 23426033PubMed |
Cerdeira, AS, O’Sullivan, J, Ohuma, EO, Harrington, D, Szafranski, P, Black, R, Mackillop, L, Impey, L, Greenwood, C, James, T, Smith, I, Papageorghiou, AT, Knight, M, and Vatish, M (2019). Randomized interventional study on prediction of preeclampsia/eclampsia in women with suspected preeclampsia. Hypertension 74, 983–990.
| Randomized interventional study on prediction of preeclampsia/eclampsia in women with suspected preeclampsia.Crossref | GoogleScholarGoogle Scholar | 31401877PubMed |
Cimadomo, D, Fabozzi, G, Vaiarelli, A, Ubaldi, N, Ubaldi, FM, and Rienzi, L (2018). Impact of maternal age on oocyte and embryo competence. Frontiers in Endocrinology 9, 327.
| Impact of maternal age on oocyte and embryo competence.Crossref | GoogleScholarGoogle Scholar | 30008696PubMed |
Cluver, CA, Hiscock, R, Decloedt, EH, Hall, DR, Schell, S, Mol, BW, Brownfoot, F, Kaitu’u-Lino, TJ, Walker, SP, and Tong, S (2021). Use of metformin to prolong gestation in preterm pre-eclampsia: randomised, double blind, placebo controlled trial. BMJ 374, n2103.
| Use of metformin to prolong gestation in preterm pre-eclampsia: randomised, double blind, placebo controlled trial.Crossref | GoogleScholarGoogle Scholar | 34551918PubMed |
Cook, SM, Grozdanovski, L, Renda, G, Santoso, D, Gorkin, R, and Senior, K (2021). Can you design the perfect condom? Engaging young people to inform safe sexual health practice and innovation. Sex Education 22, 110–122.
| Can you design the perfect condom? Engaging young people to inform safe sexual health practice and innovation.Crossref | GoogleScholarGoogle Scholar |
Cruickshank, T, MacDonald, TM, Walker, SP, Keenan, E, Dane, K, Middleton, A, Kyritsis, V, Myers, J, Cluver, C, Hastie, R, Bergman, L, Garcha, D, Cannon, P, Murray, E, Nguyen, TV, Hiscock, R, Pritchard, N, Hannan, NJ, Tong, S, and Kaitu’u-Lino, TJ (2021). Circulating growth differentiation factor 15 is increased preceding preeclampsia diagnosis: implications as a disease biomarker. Journal of the American Heart Association 10, e020302.
| Circulating growth differentiation factor 15 is increased preceding preeclampsia diagnosis: implications as a disease biomarker.Crossref | GoogleScholarGoogle Scholar | 34387117PubMed |
Darbey, A, Rebourcet, D, Curley, M, Kilcoyne, K, Jeffery, N, Reed, N, Milne, L, Roesl, C, Brown, P, and Smith, LB (2021). A comparison of in vivo viral targeting systems identifies adeno-associated virus serotype 9 (AAV9) as an effective vector for genetic manipulation of Leydig cells in adult mice. Andrology 9, 460–473.
| A comparison of in vivo viral targeting systems identifies adeno-associated virus serotype 9 (AAV9) as an effective vector for genetic manipulation of Leydig cells in adult mice.Crossref | GoogleScholarGoogle Scholar | 32996275PubMed |
Devlin, RH, and Nagahama, Y (2002). Sex determination and sex differentiation in fish: an overview of genetic, physiological, and environmental influences. Aquaculture 208, 191–364.
| Sex determination and sex differentiation in fish: an overview of genetic, physiological, and environmental influences.Crossref | GoogleScholarGoogle Scholar |
Dinh, DT, Breen, J, Akison, LK, DeMayo, FJ, Brown, HM, Robker, RL, and Russell, DL (2019). Tissue-specific progesterone receptor-chromatin binding and the regulation of progesterone-dependent gene expression. Scientific Reports 9, 11966.
| Tissue-specific progesterone receptor-chromatin binding and the regulation of progesterone-dependent gene expression.Crossref | GoogleScholarGoogle Scholar | 31427604PubMed |
Dowling, DK, and Adrian, RE (2019). Challenges and prospects for testing the Mother’s Curse hypothesis. Integrative and Comparative Biology 59, 875–889.
| Challenges and prospects for testing the Mother’s Curse hypothesis.Crossref | GoogleScholarGoogle Scholar | 31225591PubMed |
Duffy, JMN, Adamson, GD, Benson, E, Bhattacharya, S, Bhattacharya, S, Bofill, M, Brian, K, Collura, B, Curtis, C, Evers, JLH, Farquharson, RG, Fincham, A, Franik, S, Giudice, LC, Glanville, E, Hickey, M, Horne, AW, Hull, ML, Johnson, NP, Jordan, V, Khalaf, Y, Knijnenburg, JML, Legro, RS, Lensen, S, MacKenzie, J, Mavrelos, D, Mol, BW, Morbeck, DE, Nagels, H, Ng, EHY, Niederberger, C, Otter, AS, Puscasiu, L, Rautakallio-Hokkanen, S, Sadler, L, Sarris, I, Showell, M, Stewart, J, Strandell, A, Strawbridge, C, Vail, A, van Wely, M, Vercoe, M, Vuong, NL, Wang, AY, Wang, R, Wilkinson, J, Wong, K, Wong, TY, Farquhar, CM, AlAhwany, H, Balaban, O, Beebeejaun, Y, Boivin, J, Bosteels, JJA, D’Angelo, A, Dann, LF, De Jonge, CJ, du Mez, E, Ferriani, RA, Gerval, M-O, Gingel, LJ, Greenblatt, EM, Hartshorne, G, Helliwell, C, Helliwell, C, Hughes, LJ, Jo, J, Jovanović, J, Kiesel, L, Kietpeerakool, C, Kostova, E, Kucuk, T, Lawrence, RL, Lee, N, Lindemann, KE, Loto, OM, Lutjen, PJ, MacKinven, M, Mascarenhas, M, McLaughlin, H, Mills, DJ, Mourad, SM, Nguyen, LK, Norman, RJ, Olic, M, Overfield, KL, Parker-Harris, M, Ramos, DG, Rendulic, A, Repping, S, Rizzo, R, Salacone, P, Saunders, CH, Sengupta, R, Sfontouris, IA, Silverman, NR, Torrance, HL, Uphoff, EP, Wakeman, SA, Wischmann, T, Woodward, BJ, and Youssef, MA (2021). Top 10 priorities for future infertility research: an international consensus development study. Fertility and Sterility 115, 180–190.
| Top 10 priorities for future infertility research: an international consensus development study.Crossref | GoogleScholarGoogle Scholar | 33272617PubMed |
Evans, J, Salamonsen, LA, Winship, A, Menkhorst, E, Nie, G, Gargett, CE, and Dimitriadis, E (2016). Fertile ground: human endometrial programming and lessons in health and disease. Nature Reviews Endocrinology 12, 654–667.
| Fertile ground: human endometrial programming and lessons in health and disease.Crossref | GoogleScholarGoogle Scholar | 27448058PubMed |
Faas, MM, and De Vos, P (2018). Innate immune cells in the placental bed in healthy pregnancy and preeclampsia. Placenta 69, 125–133.
| Innate immune cells in the placental bed in healthy pregnancy and preeclampsia.Crossref | GoogleScholarGoogle Scholar | 29748088PubMed |
Filby, CE, Rombauts, L, Montgomery, GW, Giudice, LC, and Gargett, CE (2020). Cellular origins of endometriosis: towards novel diagnostics and therapeutics. Seminars in Reproductive Medicine 38, 201–215.
| Cellular origins of endometriosis: towards novel diagnostics and therapeutics.Crossref | GoogleScholarGoogle Scholar | 33176364PubMed |
Fox, R, Kitt, J, Leeson, P, Aye, CYL, and Lewandowski, AJ (2019). Preeclampsia: risk factors, diagnosis, management, and the cardiovascular impact on the offspring. Journal of Clinical Medicine 8, 1625.
| Preeclampsia: risk factors, diagnosis, management, and the cardiovascular impact on the offspring.Crossref | GoogleScholarGoogle Scholar |
Fuchs, F, Monet, B, Ducruet, T, Chaillet, N, and Audibert, F (2018). Effect of maternal age on the risk of preterm birth: a large cohort study. PLoS One 13, e0191002.
| Effect of maternal age on the risk of preterm birth: a large cohort study.Crossref | GoogleScholarGoogle Scholar | 29385154PubMed |
Gosnell, ME, Anwer, AG, Mahbub, SB, Menon Perinchery, S, Inglis, DW, Adhikary, PP, Jazayeri, JA, Cahill, MA, Saad, S, Pollock, CA, Sutton-McDowall, ML, Thompson, JG, and Goldys, EM (2016). Quantitative non-invasive cell characterisation and discrimination based on multispectral autofluorescence features. Scientific Reports 6, 23453.
| Quantitative non-invasive cell characterisation and discrimination based on multispectral autofluorescence features.Crossref | GoogleScholarGoogle Scholar | 27029742PubMed |
Griffiths M (1968) ‘Echidnas.’ (Pergamon Press: Oxford)
Grützner, F, Deakin, J, Rens, W, El-Mogharbel, N, and Marshall Graves, JA (2003). The monotreme genome: a patchwork of reptile, mammal and unique features? Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 136, 867–881.
| The monotreme genome: a patchwork of reptile, mammal and unique features?Crossref | GoogleScholarGoogle Scholar |
Hobbs, RM, Fagoonee, S, Papa, A, Webster, K, Altruda, F, Nishinakamura, R, Chai, L, and Pandolfi, PP (2012). Functional antagonism between Sall4 and Plzf defines germline progenitors. Cell Stem Cell 10, 284–298.
| Functional antagonism between Sall4 and Plzf defines germline progenitors.Crossref | GoogleScholarGoogle Scholar | 22385656PubMed |
Hogan, MC, Foreman, KJ, Naghavi, M, Ahn, SY, Wang, M, Makela, SM, Lopez, AD, Lozano, R, and Murray, CJL (2010). Maternal mortality for 181 countries, 1980–2008: a systematic analysis of progress towards Millennium Development Goal 5. The Lancet 375, 1609–1623.
| Maternal mortality for 181 countries, 1980–2008: a systematic analysis of progress towards Millennium Development Goal 5.Crossref | GoogleScholarGoogle Scholar |
Kleiman, RJ, and Ehlers, MD (2019). How to develop therapeutic and translational research collaborations with industry. Molecular Biology of the Cell 30, 2741–2743.
| How to develop therapeutic and translational research collaborations with industry.Crossref | GoogleScholarGoogle Scholar | 31609671PubMed |
La, HM, and Hobbs, RM (2019). Mechanisms regulating mammalian spermatogenesis and fertility recovery following germ cell depletion. Cellular and Molecular Life Sciences 76, 4071–4102.
| Mechanisms regulating mammalian spermatogenesis and fertility recovery following germ cell depletion.Crossref | GoogleScholarGoogle Scholar | 31254043PubMed |
Li, G-L, Liu, X-C, Zhang, Y, and Lin, H-R (2006). Gonadal development, aromatase activity and P450 aromatase gene expression during sex inversion of protogynous red-spotted grouper Epinephelus akaara (Temminck and Schlegel) after implantation of the aromatase inhibitor, fadrozole. Aquaculture Research 37, 484–491.
| Gonadal development, aromatase activity and P450 aromatase gene expression during sex inversion of protogynous red-spotted grouper Epinephelus akaara (Temminck and Schlegel) after implantation of the aromatase inhibitor, fadrozole.Crossref | GoogleScholarGoogle Scholar |
Li, X, Hao, Y, Elshewy, N, Zhu, X, Zhang, Z, and Zhou, P (2020). The mechanisms and clinical application of mosaicism in preimplantation embryos. Journal of Assisted Reproduction and Genetics 37, 497–508.
| The mechanisms and clinical application of mosaicism in preimplantation embryos.Crossref | GoogleScholarGoogle Scholar | 31838629PubMed |
Liu, J-F, Guiguen, Y, and Liu, S-J (2009). Aromatase (P450arom) and 11β-hydroxylase (P45011β) genes are differentially expressed during the sex change process of the protogynous rice field eel, Monopterus albus. Fish Physiology and Biochemistry 35, 511–518.
| Aromatase (P450arom) and 11β-hydroxylase (P45011β) genes are differentially expressed during the sex change process of the protogynous rice field eel, Monopterus albus.Crossref | GoogleScholarGoogle Scholar | 18807204PubMed |
Luu, TM, Katz, SL, Leeson, P, Thébaud, B, and Nuyt, A-M (2016). Preterm birth: risk factor for early-onset chronic diseases. Canadian Medical Association Journal 188, 736–746.
| Preterm birth: risk factor for early-onset chronic diseases.Crossref | GoogleScholarGoogle Scholar | 26644500PubMed |
Macklon, NS, Geraedts, JPM, and Fauser, BCJM (2002). Conception to ongoing pregnancy: the ‘black box’ of early pregnancy loss. Human Reproduction Update 8, 333–343.
| Conception to ongoing pregnancy: the ‘black box’ of early pregnancy loss.Crossref | GoogleScholarGoogle Scholar | 12206468PubMed |
Mäkelä, J-A, and Hobbs, RM (2019). Molecular regulation of spermatogonial stem cell renewal and differentiation. Reproduction 158, R169–R187.
| Molecular regulation of spermatogonial stem cell renewal and differentiation.Crossref | GoogleScholarGoogle Scholar | 31247585PubMed |
Mayaud, P, and Mabey, D (2004). Approaches to the control of sexually transmitted infections in developing countries: old problems and modern challenges. Sexually Transmitted Infections 80, 174–182.
| Approaches to the control of sexually transmitted infections in developing countries: old problems and modern challenges.Crossref | GoogleScholarGoogle Scholar | 15169997PubMed |
McKee, M (2019). Bridging the gap between research and policy and practice comment on “CIHR Health System Impact Fellows: Reflections on ‘Driving Change’ within the health system”. International Journal of Health Policy and Management 8, 557–559.
| Bridging the gap between research and policy and practice comment on “CIHR Health System Impact Fellows: Reflections on ‘Driving Change’ within the health system”.Crossref | GoogleScholarGoogle Scholar | 31657178PubMed |
Medina-Sánchez, M, and Schmidt, OG (2017). Medical microbots need better imaging and control. Nature 545, 406–408.
| Medical microbots need better imaging and control.Crossref | GoogleScholarGoogle Scholar | 28541344PubMed |
Medina-Sánchez, M, Ibarlucea, B, Pérez, N, Karnaushenko, DD, Weiz, SM, Baraban, L, Cuniberti, G, and Schmidt, OG (2016). High-performance three-dimensional tubular nanomembrane sensor for DNA detection. Nano Letters 16, 4288–4296.
| High-performance three-dimensional tubular nanomembrane sensor for DNA detection.Crossref | GoogleScholarGoogle Scholar | 27266478PubMed |
Metcalf, ES, Masterson, KR, Battaglia, D, Thompson, JG, Foss, R, Beck, R, Cook, NL, and O’Leary, T (2020). Conditions to optimise the developmental competence of immature equine oocytes. Reproduction, Fertility and Development 32, 1012–1021.
| Conditions to optimise the developmental competence of immature equine oocytes.Crossref | GoogleScholarGoogle Scholar |
Middleton, P, Gomersall, JC, Gould, JF, Shepherd, E, Olsen, SF, and Makrides, M (2018). Omega-3 fatty acid addition during pregnancy. Cochrane Database of Systematic Reviews , CD003402.
| Omega-3 fatty acid addition during pregnancy.Crossref | GoogleScholarGoogle Scholar | 30480773PubMed |
Miller, D, Motomura, K, Galaz, J, Gershater, M, Lee, ED, Romero, R, and Gomez-Lopez, N (2021). Cellular immune responses in the pathophysiology of preeclampsia. Journal of Leukocyte Biology 111, 237–260.
| Cellular immune responses in the pathophysiology of preeclampsia.Crossref | GoogleScholarGoogle Scholar | 33847419PubMed |
Mottershead, DG, Sugimura, S, Al-Musawi, SL, Li, J-J, Richani, D, White, MA, Martin, GA, Trotta, AP, Ritter, LJ, Shi, J, Mueller, TD, Harrison, CA, and Gilchrist, RB (2015). Cumulin, an Oocyte-secreted heterodimer of the transforming growth factor-β family, is a potent activator of granulosa cells and improves oocyte quality. Journal of Biological Chemistry 290, 24007–24020.
| Cumulin, an Oocyte-secreted heterodimer of the transforming growth factor-β family, is a potent activator of granulosa cells and improves oocyte quality.Crossref | GoogleScholarGoogle Scholar | 26254468PubMed |
Mulugeta, E, Wassenaar, E, Sleddens-Linkels, E, van IJcken, WFJ, Heard, E, Grootegoed, JA, Just, W, Gribnau, J, and Baarends, WM (2016). Genomes of Ellobius species provide insight into the evolutionary dynamics of mammalian sex chromosomes. Genome Research 26, 1202–1210.
| Genomes of Ellobius species provide insight into the evolutionary dynamics of mammalian sex chromosomes.Crossref | GoogleScholarGoogle Scholar | 27510564PubMed |
Newnham, JP, Dickinson, JE, Hart, RJ, Pennell, CE, Arrese, CA, and Keelan, JA (2014). Strategies to prevent preterm birth. Frontiers in Immunology 5, 584.
| Strategies to prevent preterm birth.Crossref | GoogleScholarGoogle Scholar | 25477878PubMed |
Newnham, JP, White, SW, Meharry, S, Lee, H-S, Pedretti, MK, Arrese, CA, Keelan, JA, Kemp, MW, Dickinson, JE, and Doherty, DA (2017). Reducing preterm birth by a statewide multifaceted program: an implementation study. American Journal of Obstetrics and Gynecology 216, 434–442.
| Reducing preterm birth by a statewide multifaceted program: an implementation study.Crossref | GoogleScholarGoogle Scholar | 27890647PubMed |
Piferrer, F, and Blázquez, M (2005). Aromatase distribution and regulation in fish. Fish Physiology and Biochemistry 31, 215.
| Aromatase distribution and regulation in fish.Crossref | GoogleScholarGoogle Scholar | 20035461PubMed |
Pini, T, Leahy, T, Soleilhavoup, C, Tsikis, G, Labas, V, Combes-Soia, L, Harichaux, G, Rickard, JP, Druart, X, and de Graaf, SP (2016). Proteomic investigation of ram spermatozoa and the proteins conferred by seminal plasma. Journal of Proteome Research 15, 3700–3711.
| Proteomic investigation of ram spermatozoa and the proteins conferred by seminal plasma.Crossref | GoogleScholarGoogle Scholar | 27636150PubMed |
Pini, T, de Graaf, SP, Druart, X, Tsikis, G, Labas, V, Teixeira-Gomes, AP, Gadella, BM, and Leahy, T (2018a). Binder of Sperm Proteins 1 and 5 have contrasting effects on the capacitation of ram spermatozoa. Biology of Reproduction 98, 765–775.
| Binder of Sperm Proteins 1 and 5 have contrasting effects on the capacitation of ram spermatozoa.Crossref | GoogleScholarGoogle Scholar | 29415221PubMed |
Pini, T, Farmer, K, Druart, X, Teixeira-Gomes, AP, Tsikis, G, Labas, V, Leahy, T, and de Graaf, SP (2018b). Binder of sperm proteins protect ram spermatozoa from freeze-thaw damage. Cryobiology 82, 78–87.
| Binder of sperm proteins protect ram spermatozoa from freeze-thaw damage.Crossref | GoogleScholarGoogle Scholar | 29653077PubMed |
Plante, G, Prud’homme, B, Fan, J, Lafleur, M, and Manjunath, P (2016). Evolution and function of mammalian binder of sperm proteins. Cell and Tissue Research 363, 105–127.
| Evolution and function of mammalian binder of sperm proteins.Crossref | GoogleScholarGoogle Scholar | 26386584PubMed |
Pollard, CA, and Jenkins, TG (2020). Epigenetic mechanisms within the sperm epigenome and their diagnostic potential. Best Practice & Research Clinical Endocrinology & Metabolism 34, 101481.
| Epigenetic mechanisms within the sperm epigenome and their diagnostic potential.Crossref | GoogleScholarGoogle Scholar |
Puthussery, S, Chutiyami, M, Tseng, P-C, Kilby, L, and Kapadia, J (2018). Effectiveness of early intervention programs for parents of preterm infants: a meta-review of systematic reviews. BMC Pediatrics 18, 223.
| Effectiveness of early intervention programs for parents of preterm infants: a meta-review of systematic reviews.Crossref | GoogleScholarGoogle Scholar | 29986683PubMed |
Rana, S, Lemoine, E, Granger, JP, and Karumanchi, SA (2019). Preeclampsia. Circulation Research 124, 1094–1112.
| Preeclampsia.Crossref | GoogleScholarGoogle Scholar | 30920918PubMed |
Renfree, MB, O, W-S, Short, RV, and Shaw, G (1996). Sexual differentiation of the urogenital system of the fetal and neonatal tammar wallaby, Macropus eugenii. Anatomy and Embryology 194, 111–134.
| Sexual differentiation of the urogenital system of the fetal and neonatal tammar wallaby, Macropus eugenii.Crossref | GoogleScholarGoogle Scholar | 8827321PubMed |
Rens, W, O’Brien, PCM, Grützner, F, Clarke, O, Graphodatskaya, D, Tsend-Ayush, E, Trifonov, VA, Skelton, H, Wallis, MC, Johnston, S, Veyrunes, F, Graves, JAM, and Ferguson-Smith, MA (2007). The multiple sex chromosomes of platypus and echidna are not completely identical and several share homology with the avian Z. Genome Biology 8, R243.
| The multiple sex chromosomes of platypus and echidna are not completely identical and several share homology with the avian Z.Crossref | GoogleScholarGoogle Scholar | 18021405PubMed |
Richani, D, Dunning, KR, Thompson, JG, and Gilchrist, RB (2021). Metabolic co-dependence of the oocyte and cumulus cells: essential role in determining oocyte developmental competence. Human Reproduction Update 27, 27–47.
| Metabolic co-dependence of the oocyte and cumulus cells: essential role in determining oocyte developmental competence.Crossref | GoogleScholarGoogle Scholar | 33020823PubMed |
Rickard, JP, Pini, T, Soleilhavoup, C, Cognie, J, Bathgate, R, Lynch, GW, Evans, G, Maxwell, WMC, Druart, X, and de Graaf, SP (2014). Seminal plasma aids the survival and cervical transit of epididymal ram spermatozoa. Reproduction 148, 469–478.
| Seminal plasma aids the survival and cervical transit of epididymal ram spermatozoa.Crossref | GoogleScholarGoogle Scholar | 25118301PubMed |
Robertson, SA, Green, ES, Care, AS, Moldenhauer, LM, Prins, JR, Hull, ML, Barry, SC, and Dekker, G (2019). Therapeutic potential of regulatory T cells in preeclampsia—opportunities and challenges. Frontiers in Immunology 10, 478.
| Therapeutic potential of regulatory T cells in preeclampsia—opportunities and challenges.Crossref | GoogleScholarGoogle Scholar | 30984163PubMed |
Rodríguez-Martínez, H, Kvist, U, Ernerudh, J, Sanz, L, and Calvete, JJ (2011). Seminal plasma proteins: what role do they play? American Journal of Reproductive Immunology 66, 11–22.
| Seminal plasma proteins: what role do they play?Crossref | GoogleScholarGoogle Scholar | 21726334PubMed |
Rolland, AD, Lavigne, R, Dauly, C, Calvel, P, Kervarrec, C, Freour, T, Evrard, B, Rioux-Leclercq, N, Auger, J, and Pineau, C (2013). Identification of genital tract markers in the human seminal plasma using an integrative genomics approach. Human Reproduction 28, 199–209.
| Identification of genital tract markers in the human seminal plasma using an integrative genomics approach.Crossref | GoogleScholarGoogle Scholar | 23024119PubMed |
Ross, J, and Hardee, K (2017). Use of male methods of contraception worldwide. Journal of Biosocial Science 49, 648–663.
| Use of male methods of contraception worldwide.Crossref | GoogleScholarGoogle Scholar | 27890042PubMed |
Royo, H, Polikiewicz, G, Mahadevaiah, SK, Prosser, H, Mitchell, M, Bradley, A, de Rooij, DG, Burgoyne, PS, and Turner, JMA (2010). Evidence that meiotic sex chromosome inactivation is essential for male fertility. Current Biology 20, 2117–2123.
| Evidence that meiotic sex chromosome inactivation is essential for male fertility.Crossref | GoogleScholarGoogle Scholar | 21093264PubMed |
Ryu, B-Y, Orwig, KE, Oatley, JM, Avarbock, MR, and Brinster, RL (2006). Effects of aging and niche microenvironment on spermatogonial stem cell self-renewal. Stem Cells 24, 1505–1511.
| Effects of aging and niche microenvironment on spermatogonial stem cell self-renewal.Crossref | GoogleScholarGoogle Scholar | 16456131PubMed |
Schjenken, JE, and Robertson, SA (2020). The female response to seminal fluid. Physiological Reviews 100, 1077–1117.
| The female response to seminal fluid.Crossref | GoogleScholarGoogle Scholar | 31999507PubMed |
Schwarz, L, Medina-Sánchez, M, and Schmidt, OG (2019). Sperm-hybrid micromotors: on-board assistance for nature’s bustling swimmers. Reproduction 159, R83–R96.
| Sperm-hybrid micromotors: on-board assistance for nature’s bustling swimmers.Crossref | GoogleScholarGoogle Scholar |
Schwarz, L, Karnaushenko, DD, Hebenstreit, F, Naumann, R, Schmidt, OG, and Medina-Sánchez, M (2020). A rotating spiral micromotor for noninvasive zygote transfer. Advanced Science 7, 2000843.
| A rotating spiral micromotor for noninvasive zygote transfer.Crossref | GoogleScholarGoogle Scholar | 32999835PubMed |
Simmonds, LA, Sullivan, TR, Skubisz, M, Middleton, PF, Best, KP, Yelland, LN, Quinlivan, J, Zhou, SJ, Liu, G, McPhee, AJ, Gibson, RA, and Makrides, M (2020). Omega-3 fatty acid supplementation in pregnancy—baseline omega-3 status and early preterm birth: exploratory analysis of a randomised controlled trial. BJOG: An International Journal of Obstetrics & Gynaecology 127, 975–981.
| Omega-3 fatty acid supplementation in pregnancy—baseline omega-3 status and early preterm birth: exploratory analysis of a randomised controlled trial.Crossref | GoogleScholarGoogle Scholar |
Stepan, H, Hund, M, and Andraczek, T (2020). Combining biomarkers to predict pregnancy complications and redefine preeclampsia. Hypertension 75, 918–926.
| Combining biomarkers to predict pregnancy complications and redefine preeclampsia.Crossref | GoogleScholarGoogle Scholar | 32063058PubMed |
Stocker, WA, Walton, KL, Richani, D, Chan, KL, Beilby, KH, Finger, BJ, Green, MP, Gilchrist, RB, and Harrison, CA (2020). A variant of human growth differentiation factor-9 that improves oocyte developmental competence. Journal of Biological Chemistry 295, 7981–7991.
| A variant of human growth differentiation factor-9 that improves oocyte developmental competence.Crossref | GoogleScholarGoogle Scholar | 32350111PubMed |
Striggow, F, Medina-Sánchez, M, Auernhammer, GK, Magdanz, V, Friedrich, BM, and Schmidt, OG (2020). Sperm-driven micromotors moving in oviduct fluid and viscoelastic media. Small 16, 2000213.
| Sperm-driven micromotors moving in oviduct fluid and viscoelastic media.Crossref | GoogleScholarGoogle Scholar |
Sully E, Biddlecom A, Darroch JE, Riley T, Ashford LS, Lince-Deroche N, Firestein L, Murro R (2020) Adding it up: investing in sexual and reproductive health 2019. The Guttmacher Institute, New York, New York. Available at https://www.guttmacher.org/report/adding-it-up-investing-in-sexual-reproductive-health-2019
Tan, TCY, Mahbub, SB, Campbell, JM, Habibalahi, A, Campugan, CA, Rose, RD, Chow, DJX, Mustafa, S, Goldys, EM, and Dunning, KR (2021). Non-invasive, label-free optical analysis to detect aneuploidy within the inner cell mass of the preimplantation embryo. Human Reproduction 37, 14–29.
| Non-invasive, label-free optical analysis to detect aneuploidy within the inner cell mass of the preimplantation embryo.Crossref | GoogleScholarGoogle Scholar | 34741175PubMed |
Todd, EV, Ortega-Recalde, O, Liu, H, Lamm, MS, Rutherford, KM, Cross, H, Black, MA, Kardailsky, O, Marshall Graves, JA, Hore, TA, Godwin, JR, and Gemmell, NJ (2019). Stress, novel sex genes, and epigenetic reprogramming orchestrate socially controlled sex change. Science Advances 5, eaaw7006.
| Stress, novel sex genes, and epigenetic reprogramming orchestrate socially controlled sex change.Crossref | GoogleScholarGoogle Scholar | 31309157PubMed |
Ubaldi, FM, Cimadomo, D, Vaiarelli, A, Fabozzi, G, Venturella, R, Maggiulli, R, Mazzilli, R, Ferrero, S, Palagiano, A, and Rienzi, L (2019). Advanced maternal age in IVF: still a challenge? The present and the future of its treatment. Frontiers in Endocrinology 10, 94.
| Advanced maternal age in IVF: still a challenge? The present and the future of its treatment.Crossref | GoogleScholarGoogle Scholar | 30842755PubMed |
Wallis, MC, Waters, PD, and Graves, JAM (2008). Sex determination in mammals — before and after the evolution of SRY. Cellular and Molecular Life Sciences 65, 3182.
| Sex determination in mammals — before and after the evolution of SRY.Crossref | GoogleScholarGoogle Scholar | 18581056PubMed |
Wanderer, JP, Leffert, LR, Mhyre, JM, Kuklina, EV, Callaghan, WM, and Bateman, BT (2013). Epidemiology of obstetric-related ICU admissions in Maryland: 1999–2008. Critical Care Medicine 41, 1844–1852.
| Epidemiology of obstetric-related ICU admissions in Maryland: 1999–2008.Crossref | GoogleScholarGoogle Scholar | 23648568PubMed |
Waters, PD, and Ruiz-Herrera, A (2020). Meiotic executioner genes protect the Y from extinction. Trends in Genetics 36, 728–738.
| Meiotic executioner genes protect the Y from extinction.Crossref | GoogleScholarGoogle Scholar | 32773168PubMed |
Willems, A, Roesl, C, Mitchell, RT, Milne, L, Jeffery, N, Smith, S, Verhoeven, G, Brown, P, and Smith, LB (2015). Sertoli cell androgen receptor signalling in adulthood is essential for post-meiotic germ cell development. Molecular Reproduction and Development 82, 626–627.
| Sertoli cell androgen receptor signalling in adulthood is essential for post-meiotic germ cell development.Crossref | GoogleScholarGoogle Scholar | 26061432PubMed |
Wolff, JN, Gemmell, NJ, Tompkins, DM, and Dowling, DK (2017). Introduction of a male-harming mitochondrial haplotype via ‘Trojan Females’ achieves population suppression in fruit flies. eLife 6, e23551.
| Introduction of a male-harming mitochondrial haplotype via ‘Trojan Females’ achieves population suppression in fruit flies.Crossref | GoogleScholarGoogle Scholar | 28467301PubMed |
Woodsong, C, and Koo, HP (1999). Two good reasons: women’s and men’s perspectives on dual contraceptive use. Social Science & Medicine 49, 567–580.
| Two good reasons: women’s and men’s perspectives on dual contraceptive use.Crossref | GoogleScholarGoogle Scholar |
Xu, H, Medina-Sánchez, M, Magdanz, V, Schwarz, L, Hebenstreit, F, and Schmidt, OG (2018). Sperm-hybrid micromotor for targeted drug delivery. ACS Nano 12, 327–337.
| Sperm-hybrid micromotor for targeted drug delivery.Crossref | GoogleScholarGoogle Scholar | 29202221PubMed |
Xu, H, Medina-Sánchez, M, Maitz, MF, Werner, C, and Schmidt, OG (2020). Sperm micromotors for cargo delivery through flowing blood. ACS Nano 14, 2982–2993.
| Sperm micromotors for cargo delivery through flowing blood.Crossref | GoogleScholarGoogle Scholar | 32096976PubMed |
Yee, WKW, Sutton, KL, and Dowling, DK (2013). In vivo male fertility is affected by naturally occurring mitochondrial haplotypes. Current Biology 23, R55–R56.
| In vivo male fertility is affected by naturally occurring mitochondrial haplotypes.Crossref | GoogleScholarGoogle Scholar |
Zeisler, H, Llurba, E, Chantraine, F, Vatish, M, Staff, AC, Sennström, M, Olovsson, M, Brennecke, SP, Stepan, H, Allegranza, D, Dilba, P, Schoedl, M, Hund, M, and Verlohren, S (2016). Predictive value of the sFlt-1:PlGF ratio in women with suspected preeclampsia. New England Journal of Medicine 374, 13–22.
| Predictive value of the sFlt-1:PlGF ratio in women with suspected preeclampsia.Crossref | GoogleScholarGoogle Scholar | 26735990PubMed |
Zhang, Y, Zhang, W, Yang, H, Zhou, W, Hu, C, and Zhang, L (2008). Two cytochrome P450 aromatase genes in the hermaphrodite ricefield eel Monopterus albus: mRNA expression during ovarian development and sex change. Journal of Endocrinology 199, 317–331.
| Two cytochrome P450 aromatase genes in the hermaphrodite ricefield eel Monopterus albus: mRNA expression during ovarian development and sex change.Crossref | GoogleScholarGoogle Scholar | 18728127PubMed |
Zhou, W, and Dimitriadis, E (2020). Secreted MicroRNA to predict embryo implantation outcome: from research to clinical diagnostic application. Frontiers in Cell and Developmental Biology 8, 586510.
| Secreted MicroRNA to predict embryo implantation outcome: from research to clinical diagnostic application.Crossref | GoogleScholarGoogle Scholar | 33072767PubMed |
Zhou, Y, Shearwin-Whyatt, L, Li, J, Song, Z, Hayakawa, T, Stevens, D, Fenelon, JC, Peel, E, Cheng, Y, Pajpach, F, Bradley, N, Suzuki, H, Nikaido, M, Damas, J, Daish, T, Perry, T, Zhu, Z, Geng, Y, Rhie, A, Sims, Y, Wood, J, Haase, B, Mountcastle, J, Fedrigo, O, Li, Q, Yang, H, Wang, J, Johnston, SD, Phillippy, AM, Howe, K, Jarvis, ED, Ryder, OA, Kaessmann, H, Donnelly, P, Korlach, J, Lewin, HA, Graves, J, Belov, K, Renfree, MB, Grutzner, F, Zhou, Q, and Zhang, G (2021). Platypus and echidna genomes reveal mammalian biology and evolution. Nature 592, 756–762.
| Platypus and echidna genomes reveal mammalian biology and evolution.Crossref | GoogleScholarGoogle Scholar | 33408411PubMed |
