
TY  - JOUR
A1  - Mccoll, SR 
A1  - Daniels, CB 
T1  - A Comparison Between the Inflammatory Mediators Produced by the Blue-Tongue Lizard (Tiliqua-Scincoides) and Human White Blood-Cells
JF  - Australian Journal of Zoology
JO  - Aust. J. Zool.
Y1  - 1988
VL  - 36
IS  - 2
SP  - 209
EP  - 215
KW  - 
UR  - https://doi.org/10.1071/ZO9880209 
N2  - Human white blood cells, particularly neutrophils and macrophages produce several biologically active molecules including oxygen-derived free radicals and some metabolites of arachidonic acid which are involved in mechanisms of host defence. White blood cells of the blue-tongue lizard Tiliqua scincoides produce certain derivatives of arachidonic acid which include prostaglandins, thromboxane and 12- and 15-hydroxyeicosatetraenoic acid. The ability to produce these compounds indicates that these animals possess the enzymes cyclooxygenase, 12- and 15-lipoxygenase, T. scincoides white blood cells did not produce leukotriene B4 or 5-hydroxyeicosatetraenoic acid indicating that, unlike human white blood cells, they do not possess a 5-lipoxygenase enxyme. T. scincoides cells are also capable of producing the oxygen-derived free radical superoxide enzyme. 
ER  -

