
%0 Journal Article
%A Riggs, AD 
%T Marsupials and Mechanisms of X-Chromosome Inactivation
%J Australian Journal of Zoology
%D 1989/04/01
%V 37
%N 3
%P 419-441
%K 
%R https://doi.org/10.1071/ZO9890419
%U https://www.publish.csiro.au/paper/ZO9890419 
%X X chromosome inactivation is reviewed with molecular mechanisms in mind. Models for the various steps leading to the establishment and maintenance of X inactivation are discussed, with comparisons between eutherians and marsupials included. Late DNA replication is proposed to be an epigenetic, self-propagating mechanism aiding the somatic inheritance of determined states, and thus could be the ancestral mechanism for X inactivation. Also, a novel mechanism, Type I DNA-reeling, is proposed to maintain higher order chromosome structure and to help explain the cis-spreading of X inactivation. 
