Selective Degradation by Bromine Water of the Polypeptide Chains of Oxidized Insulin

Abstract

In degradative work on oxytocin (Mueller, Pierce, and du Vigneaud 1953; Ressler, Trippett, and du Vigneaud 1953; du Vigneaud et al. 1954) it was found that whereas oxidation with performic acid gave a single product (I), oxidation with $bromine\; water\; or\; treatment\; of\; (I)\; with\; bromine\; water\; gave\; two\; peptide\; fragments,\; resulting\; from\; cleavage\; of\; a\; dibromotyrosylisoleucyl\; bond.$