The Response to Artificial Selection Due to Autosomal Genes of Large Effect II. The Effects of Linkage on Limits to Selection in Finite Populations

Abstract

The limits to artificial selection for pairs of linked additive loci of equal proportionate effect, starting from a base population in linkage equilibrium, have been studied by means of a simulation technique on a CDC 3600 computer. Particular attention has been paid to the case of genes of large effect, making use of the definition of the selective value of a genotype given in the first paper of this series.