Inhibition by Plant Growth Retardants of Cholesterol Biosynthesis in Slices of Rat Liver and Hepatoma

Abstract

The plant growth retardant Phosfon inhibits cholesterol formation by cell·free preparations of normal liver and the Morris hepatomas 5123C, 7794A, and 9618A. In addition, both Phosfon and Amo 1618 arc active in inhibiting cholesterol synthesis from acetate and mevalonate in slices of host liver and the hepatomas. Fatty acid synthesis from acetate was also reduced in the presence of the retardants.