Lectins, Calcium Ionophore A23187 and Peanut Oil as Deciduogenic Agents in the Uterus of Pseudopregnant Mice: Effects of Tranylcypromine, Indomethacin, Iproniazid and Propanolol

Abstract

Intraluminal injections of lectins, including concanavalin A (Con A), wheatgerm lectin, and soybean lectin, Con A-Sepharose 4B beads, calcium ionophore A23187 or peanut oil into the left uterine horns of mice on day 4 of pseudopregnancy induced the formation of deciduomata and significantly increased the weight and alkaline phosphatase activity of uterine tissue on day 7 of pseudopregnancy. In contrast, injections of these materials into the uterine horns of non-pseudopregnant mice that had not been previously mated failed to induce similar responses.