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Official Journal of the Australasian College for Infection Prevention and Control
RESEARCH ARTICLE

Report of a case of neonatal malaria (Plasmodium falciparum) in Nigeria

Oyebola Fasugba
+ Author Affiliations
- Author Affiliations

School of Nursing, Midwifery and Paramedicine, Australian Catholic University, PO Box 256, Dickson, ACT 2602, Australia. Email: oyebola.fasugba@acu.edu.au

Healthcare Infection 17(4) 122-126 https://doi.org/10.1071/HI12024
Submitted: 9 July 2012  Accepted: 18 October 2012   Published: 15 November 2012

Abstract

Neonatal malaria has been considered to be rare even in malaria-endemic areas and this assumption has led to a significant proportion of neonates with malaria being missed or wrongly diagnosed. A case is reported of a 15-day-old female with Plasmodium falciparum malaria in Lagos, Nigeria. An initial diagnosis of septicaemia was made and peripheral blood film for malaria parasite was not included among the laboratory investigations due to a low index of suspicion for malaria in this age group. The diagnosis of neonatal malaria was eventually made after poor improvement in the clinical state of the baby prompting microscopic examination for malaria parasite in the patient’s blood. The patient was successfully treated and recovered without any complications. Knowledge of the prevalence of malaria in neonates will ensure screening for malaria parasite is included as part of the routine investigations or sepsis work-up for all neonates with fever. As non-endemic countries such as Australia continue to receive a high number of immigrants from neighbouring and distant malaria endemic regions, it is imperative to consider this condition in babies of mothers who have recently travelled to or emigrated from a malaria-endemic region. This has implications for infection control professionals and travel medicine clinics as they need to have a good understanding of malaria to provide expert advice and manage patients appropriately.


References

[1]  World Health Organization. World Malaria Report 2011. Available from: http://www.who.int/malaria/world_malaria_report_2011/9789241564403_eng.pdf [verified 10 September 2012].

[2]  Uneke C. Congenital Plasmodium falciparum malaria in sub-Saharan Africa: a rarity or frequent occurrence? Parasitol Res 2007; 101 835–42.
Congenital Plasmodium falciparum malaria in sub-Saharan Africa: a rarity or frequent occurrence?Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD2svlsVWgtQ%3D%3D&md5=b5d87f15ce99e0f9963dff371eacd2d1CAS |

[3]  Karunamoorthi K. Vector control: a cornerstone in the malaria elimination campaign. Clin Microbiol Infect 2011; 17 1608–16.
Vector control: a cornerstone in the malaria elimination campaign.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC3MbhtVCjug%3D%3D&md5=23126db42902ff80419266fcf282020bCAS |

[4]  Fischer PR. Malaria and newborns. J Trop Pediatr 2003; 49 132–5.
Malaria and newborns.Crossref | GoogleScholarGoogle Scholar |

[5]  Mwangoka G, Kimera S, Mboera L. Congenital Plasmodium falciparum infection in neonates in Muheza District, Tanzania. Malar J 2008; 7 117
Congenital Plasmodium falciparum infection in neonates in Muheza District, Tanzania.Crossref | GoogleScholarGoogle Scholar |

[6]  Mukhtar MY, Lesi FEA, Iroha EU, Egri-Okwaji MTC, Mafe AG. Congenital malaria among inborn babies at a tertiary centre in Lagos, Nigeria. J Trop Pediatr 2006; 52 19–23.
Congenital malaria among inborn babies at a tertiary centre in Lagos, Nigeria.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD28%2FltFSmtA%3D%3D&md5=96f15a9957dd856a90018d6abaeb87daCAS |

[7]  Okechukwu AA, Olateju K. Symptomatic and asymptomatic neonatal malaria in Abuja. J Med Med Sci 2011; 2 722–7.

[8]  Sotimehin SAA, Runsewe-Abiodun TIA, Oladapo OTB, Njokanma OFC, Olanrewaju DM. Possible risk factors for congenital malaria at a tertiary care hospital in Sagamu, Ogun State, South-West Nigeria. J Trop Pediatr 2008; 54 313–20.
Possible risk factors for congenital malaria at a tertiary care hospital in Sagamu, Ogun State, South-West Nigeria.Crossref | GoogleScholarGoogle Scholar |

[9]  Falade C, Mokuolu O, Okafor H, Orogade A, Falade A, Adedoyin O, et al Epidemiology of congenital malaria in Nigeria: a multi-centre study. Trop Med Int Health 2007; 12 1279–87.
Epidemiology of congenital malaria in Nigeria: a multi-centre study.Crossref | GoogleScholarGoogle Scholar |

[10]  Lesi FE, Mukhtar MY, Iroha EU, Egri-Okwaji MT. Clinical presentation of congenital malaria at the Lagos University Teaching Hospital. Niger J Clin Pract 2010; 13 134–8.
| 1:STN:280:DC%2BC3czmt1yiuw%3D%3D&md5=2c108334f8081487d161890d0375c2baCAS |

[11]  Mendis K, Rietveld A, Warsame M, Bosman A, Greenwood B, Wernsdorfer WH. From malaria control to eradication: The WHO perspective. Trop Med Int Health 2009; 14 802–9.
From malaria control to eradication: The WHO perspective.Crossref | GoogleScholarGoogle Scholar |

[12]  Centre for Disease Control. Malaria guidelines for health professionals in the Northern Territory. 5th edn. Casuarina, NT: Centre for Disease Control, Department of Health and Community Service, Royal Darwin Hospital; 2007. Available from: http://www.health.nt.gov.au/library/scripts/objectifyMedia.aspx?file=pdf/10/94.pdf&siteID=1&str_title=Malaria.pdf [verified 3 September 2012].

[13]  Stäger K, Legros F, Krause G, Low N, Bradley D, Desai M, et al Imported malaria in children in industralized countries, 1992–2002. Emerg Infect Dis 2009; 15 185–91.
Imported malaria in children in industralized countries, 1992–2002.Crossref | GoogleScholarGoogle Scholar |

[14]  Hyacinth IH, Oguche S, Yilgwan CS. Summary description of 24 cases of neonatal malaria seen at a tertiary health center in Nigeria. Iran J Pediatr. 2012; 22 87–91.

[15]  Idowu OA, Mafiana CF, Dapo S. Malaria among pregnant women in Abeokuta, Nigeria Tanzania Health. Res Bull (Sun Chiwawitthaya Thang Thale Phuket) 2006; 8 28–31.
| 1:STN:280:DC%2BD28nitFWmsQ%3D%3D&md5=c860cb895ce82334b24cf0fd80af34d0CAS |

[16]  Rogerson SJ, Van den Broek NR, Chaluluka E, Qongwane C, Mhango CG, Molyneux ME. Malaria and anaemia in antenatal women in Blantyre, Malawi: a twelve-months survey. Am J Trop Med Hyg 2000; 62 335–40.
| 1:STN:280:DC%2BD3cvoslGitA%3D%3D&md5=cc56d0272cf7717d9f6287cf9ae64e02CAS |

[17]  Espinosa FM, Alecrim WD, Daniel-Ribeiro CT. Attraction of mosquitoes to pregnant women. Lancet 2000; 356 685
Attraction of mosquitoes to pregnant women.Crossref | GoogleScholarGoogle Scholar |

[18]  Allen SJ, Raiko A, O’Donnell A, Alexander NDE, Clegg JB. Causes of preterm delivery and intrauterine growth retardation in a malaria endemic region of Papua New Guinea. Arch Dis Child Fetal Neonatal Ed 1998; 79 F135–40.
Causes of preterm delivery and intrauterine growth retardation in a malaria endemic region of Papua New Guinea.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK1M%2Fks1Wrsw%3D%3D&md5=61fb1e58cfc0cd0c171ed3c64bd1f334CAS |

[19]  Schwarz NG, Adegnika AA, Breitling LP, Gabor J, Agnandji ST, Newman RD, et al Placental malaria increases malaria risk in the first 30 months of life. Clin Infect Dis 2008; 47 1017–25.
Placental malaria increases malaria risk in the first 30 months of life.Crossref | GoogleScholarGoogle Scholar |

[20]  Ibhanesebhor SE. Clinical characteristics of neonatal malaria. J Trop Pediatr 1995; 41 330–3.
| 1:STN:280:DyaK287ptlCntw%3D%3D&md5=99d50e92e09b2a24aeac3528c530a6abCAS |

[21]  Uneke C. Congenital malaria: an overview. Tanz J Health Res 2011; 13 1–17.

[22]  Kothare SV, Kallapur SG, Irani SF, Prabhu SB, Gangal PS, Agarwal GJ. Congenital malaria (a report of 2 cases). J Postgrad Med 1987; 33 158–61.
| 1:STN:280:DyaL1c7hvVeqtA%3D%3D&md5=5fb0246ebe0a2bbd16a8b8c5d7bc6464CAS |

[23]  Ekanem AD, Anah MU, Udo JJ. The prevalence of congenital malaria among neonates with suspected sepsis in Calabar, Nigeria. Trop Doct 2008; 38 73–6.
The prevalence of congenital malaria among neonates with suspected sepsis in Calabar, Nigeria.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD1c3ptlSrsg%3D%3D&md5=d1c37cc28a17739868fed25b2214269aCAS |

[24]  World Health Organization. Guidelines for the treatment of Malaria. Available from: http://apps.who.int/malaria/docs/TreatmentGuidelines2006.pdf [verified 3 September 2012]

[25]  Gray TJ, Trauer JM, Fairley M, Krause VL, Markey PG. Imported malaria in the Northern Territory, Australia – 428 consecutive cases. Commun Dis Intell 2012; 36 107–13.

[26]  Robinson P, Jenney AW, Tachado M, Yung A, Manitta J, Taylor K, et al Imported malaria treated in Melbourne, Australia: epidemiology and clinical features in 246 patients. J Travel Med 2001; 8 76–81.
Imported malaria treated in Melbourne, Australia: epidemiology and clinical features in 246 patients.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD3M3ms1aksA%3D%3D&md5=2f41f7eb474b35d045e1634cd03bb9acCAS |

[27]  Massey P, Durrheim DN, Speare R. Inadequate chemoprophylaxis and the risk of malaria. Aust Fam Physician 2007; 36 1058–60.

[28]  Charles DM, Hart J, Davis WA, Sullivan E, Dowse GK, Davis TME. Notifications of imported malaria in Western Australia, 1990–2001: incidence, associated factors and chemoprophylaxis. Med J Aust 2005; 182 164–7.

[29]  Fischer PR. Congenital malaria: an African survey. J Clin Pediatr 1997; 36 411–3.
Congenital malaria: an African survey.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK2szosFCltw%3D%3D&md5=dbe22bceba95ce3228baafb64cf0289dCAS |

[30]  Mueller I, Rogerson S, Mola GDL, Reeder JC. A review of the current state of malaria among pregnant women in Papua New Guinea. PNG Med J 2008; 51 12–6.

[31]  Lehner PJ, Andrews CJ. Congenital malaria in Papua New Guinea. Trans R Soc Trop Med Hyg 1988; 82 822–6.
Congenital malaria in Papua New Guinea.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaL1MzovV2msg%3D%3D&md5=3a0948f826e8f7034c0f52082a50cbf1CAS |

[32]  Lesko CR, Arguin PM, Newman RD. Congenital malaria in the United States: a review of cases from 1966 to 2005. Arch Pediatr Adolesc Med 2007; 161 1062–7.
Congenital malaria in the United States: a review of cases from 1966 to 2005.Crossref | GoogleScholarGoogle Scholar |