The Effects of Oestrogens and Anti-Oestrogens On Ovum Transport in the Laboratory Mouse.

Abstract

Suitable doses of the anti-oestrogens DMS, MER 25, and MRL 37 given to mice on the first 3 days after mating caused retention in the oviduct of all ova (predominantly in the ampulla) until at least day 4, and prevented implantation but did not cause the loss of many ova. MER 25 caused tube-locking of ova in only about 50% of mice, but implantation did not occur although apparently normal blastocysts were present in the uterus on day 4. DMS, the most oestrogenic of the three compounds, markedly reduced the recovery of ova after day 4. The blastocoele in the oviducal ova found in control and treated mice on day 4 was not as well developed as in uterine ova