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The effectiveness of prophylaxis for measles contacts in NSW
Vicky
Sheppeard A B F,
Bradley
Forssman C,
Mark J.
Ferson D,
Conrad
Moreira B,
Sue
Campbell-Lloyd A,
Dominic E.
Dwyer E,
Jeremy M.
McAnulty A
A
Centre for Health Protection, NSW Department of Health
B
Centre for Population Health, Sydney West Area Health Service
C
School of Public Health, University of Sydney
D
Public Health Unit, South Eastern Sydney Illawarra Area Health Service and School of Public Health and Community Medicine, University of NSW
E
Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital
F
Corresponding author. Email: vicky.sheppeard@swahs.health.nsw.gov.au
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New South Wales Public Health Bulletin 20(6) 81–85 http://dx.doi.org/10.1071/NB08014
Published online: 24 June 2009
Abstract
Objectives: As international estimates of the effectiveness of post-exposure prophylaxis of measles vary, we sought to determine the effectiveness of post-exposure prophylaxis with either vaccine or immunoglobulin in susceptible persons with known measles contact. Methods: Data were obtained on all cases of measles notified in NSW between 1 March and 31 May 2006 and their contacts. The effectiveness of prophylaxis was calculated using the cohort method. Results: During March to May 2006, 57 cases of measles were notified and 1760 measles contacts were identified, of which 553 were classified as susceptible. The calculated effectiveness of post-exposure prophylaxis with vaccine or immunoglobulin in preventing measles was 83.3% (95% CI: 27–96%). Conclusion: Post-exposure immunisation remains an effective tool for preventing secondary cases of measles.
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