A public health clinic was established to provide antiviral prophylaxis to school contacts during the pandemic (H1N1) 2009 influenza outbreak in NSW, Australia. Children (n = 74) and staff (n = 9) were provided with antiviral (oseltamivir) prophylaxis following exposure to a confirmed case of pandemic (H1N1) 2009 influenza. The success of the clinic included attention to infection control and quarantining of potentially infectious children and staff, attendance at the clinic of pharmacists to ensure accurate dispensing of suspension medication, availability of experienced public health staff at short notice, and provision of accurate information to staff, school children and families attending the clinic.