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REVIEW

Integration of energy and protein transactions in the body to build new tools for predicting performance and body composition of ruminants

V. H. Oddy A D , H. C. Dougherty B and J. W. Oltjen C
+ Author Affiliations
- Author Affiliations

A NSW Department of Primary Industries, Livestock Industries Centre, Trevanna Road, University of New England, Armidale, NSW 2351, Australia.

B Department of Animal Science, W049 The Woolshed, University of New England, Armidale, NSW 2351, Australia.

C Department of Animal Science, One Shields Avenue, University of California, Davis, CA 95616, USA.

D Corresponding author. Email: hutton.oddy@dpi.nsw.gov.au

Animal Production Science 59(11) 1970-1979 https://doi.org/10.1071/AN19229
Submitted: 18 April 2019  Accepted: 24 July 2019   Published: 16 September 2019

Abstract

Increased market pressure to improve meat yield and quality require improved methods of predicting body composition in growing animals. Current systems of animal nutrition based on nutrient supply and animal characteristics predict animal growth from nutrient inputs, but, as of yet, do not accurately predict body composition. The present paper explores the evidence and data required to support an existing model of the effects of energy intake on visceral and muscle protein mass and energy expenditure to predict heat production, growth and body composition of sheep. While parameters of the model related to energetic costs of protein in muscle and viscera can be supported by independent studies, parameters associated with energetic costs of protein gain, particularly in viscera, are harder to reconcile with independent measurements. The range of available data on systematic changes in visceral organ mass over time in response to feed intake is limited, which may constrain generalisation of the parameters of the model with regard to the wide range of production situations faced by the sheep and cattle industries. However, sufficient data exist in the literature to test, and if required, revise the current framework.

Additional keywords: cattle, modelling, protein metabolism, ruminant nutrition, sheep.


References

Adeola O, Young LG, McBride BW, Ball RO (1989) In vitro Na+, K+-ATPase (EC 3.6.1.3)-dependent respiration and protein synthesis in skeletal muscle of pigs fed at three dietary protein levels. British Journal of Nutrition 61, 453–465.
In vitro Na+, K+-ATPase (EC 3.6.1.3)-dependent respiration and protein synthesis in skeletal muscle of pigs fed at three dietary protein levels.Crossref | GoogleScholarGoogle Scholar | 2547426PubMed |

Attaix D, Remond D, Savary-Auzeloux IC (2005) Protein metabolism and turnover. In ‘Quantitative aspects of ruminant digestion and metabolism’, 2nd edn. (Eds J Dijkstra, JM Forbes, J France) pp. 373–397. (CABI: Wallingford, UK)

Baldwin RL, Black JL (1979) ‘Simulation of the effects of nutritional and physiological status on the growth of mammalian tissues: description and evaluation of a computer program.’ Animal Research Laboratories Technical Paper No. 6. pp. 1–35. (CSIRO: Melbourne)

Ball AJ (1996) Changes in body composition and maintenance efficiency during periods of restricted and maintenance feeding in immature and mature sheep. PhD Thesis, University of New England, Armidale, NSW, Australia.

Bermingham EN, Nozière P, Vernet J, Lapierre H, Léger S, Sauvant D, Ortigues-Marty I (2008) The relationships between intake and net portal fluxes of energy metabolites in ruminants: a meta-analysis. Animal Feed Science and Technology 143, 27–58.
The relationships between intake and net portal fluxes of energy metabolites in ruminants: a meta-analysis.Crossref | GoogleScholarGoogle Scholar |

Burrin DG, Ferrell CL, Eisemann JH, Britton RA, Nienaber JA (1989) Effect of level of nutrition on splanchnic blood flow and oxygen consumption in sheep. British Journal of Nutrition 62, 23–34.
Effect of level of nutrition on splanchnic blood flow and oxygen consumption in sheep.Crossref | GoogleScholarGoogle Scholar | 2789987PubMed |

Burrin DG, Ferrell CL, Britton RA, Bauer M (1990) Level of nutrition and visceral organ size and metabolic activity in sheep. British Journal of Nutrition 64, 439–448.
Level of nutrition and visceral organ size and metabolic activity in sheep.Crossref | GoogleScholarGoogle Scholar | 2223745PubMed |

Connell A, Calder AG, Anderson SE, Lobley GE (1997) Hepatic protein synthesis in the sheep: effect of intake as monitored by use of stable-isotope-labelled glycine, leucine and phenylalanine. British Journal of Nutrition 77, 255–271.
Hepatic protein synthesis in the sheep: effect of intake as monitored by use of stable-isotope-labelled glycine, leucine and phenylalanine.Crossref | GoogleScholarGoogle Scholar | 9135371PubMed |

Di Marco ON, Baldwin RL, Calvert CC (1989) Simulation of DNA, protein and fat accretion in growing steers. Agricultural Systems 29, 21–34.
Simulation of DNA, protein and fat accretion in growing steers.Crossref | GoogleScholarGoogle Scholar |

Early RJ, McBride BW, Ball RO (1988) Phenylalanine metabolism in sheep infused with glucose plus insulin II. Effects on in vivo and in vitro protein synthesis and related energy expenditures. Canadian Journal of Animal Science 68, 721–730.
Phenylalanine metabolism in sheep infused with glucose plus insulin II. Effects on in vivo and in vitro protein synthesis and related energy expenditures.Crossref | GoogleScholarGoogle Scholar |

Ferrell CL (1988) Contribution of visceral organs to animal energy expenditures. Journal of Animal Science 66, 23–34.

Ferrell CL, Koong LJ, Nienaber JA (1986) Effect of previous nutrition on body composition and maintenance energy costs of growing lambs. British Journal of Nutrition 56, 595–605.
Effect of previous nutrition on body composition and maintenance energy costs of growing lambs.Crossref | GoogleScholarGoogle Scholar | 3676234PubMed |

Fisher DJ, Heymann MA, Rudolph AM (1981) Myocardial consumption of oxygen and carbohydrates in newborn sheep. Pediatric Research 15, 843–846.
Myocardial consumption of oxygen and carbohydrates in newborn sheep.Crossref | GoogleScholarGoogle Scholar | 7243385PubMed |

Fluharty FL, McClure KE (1997) Effects of dietary energy intake and protein concentration on performance and visceral organ mass in lambs. Journal of Animal Science 75, 604–610.
Effects of dietary energy intake and protein concentration on performance and visceral organ mass in lambs.Crossref | GoogleScholarGoogle Scholar | 9078474PubMed |

Fluharty FL, McClure KE, Solomon MB, Clevenger DD, Lowe GD (1999) Energy source and ionophore supplementation effects on lamb growth, carcass characteristics, visceral organ mass, diet digestibility and nitrogen metabolism. Journal of Animal Science 77, 816–823.
Energy source and ionophore supplementation effects on lamb growth, carcass characteristics, visceral organ mass, diet digestibility and nitrogen metabolism.Crossref | GoogleScholarGoogle Scholar | 10328344PubMed |

Freetly HC, Ferrell CL, Jenkins TG, Goetsch AL (1995) Visceral oxygen consumption during chronic feed restriction and realimentation in sheep. Journal of Animal Science 73, 843–852.
Visceral oxygen consumption during chronic feed restriction and realimentation in sheep.Crossref | GoogleScholarGoogle Scholar | 7608019PubMed |

Gill M, France J, Summers M, McBride BW, Milligan LP (1989) Simulation of the energy costs associated with protein turnover and Na+, K+-transport in growing lambs The Journal of Nutrition 119, 1287–1299.
Simulation of the energy costs associated with protein turnover and Na+, K+-transport in growing lambsCrossref | GoogleScholarGoogle Scholar | 2795242PubMed |

Graham NMcC, Searle TW, Griffiths DA (1974) Basal metabolic rate in lambs and young sheep. Australian Journal of Agricultural Research 25, 957–971.
Basal metabolic rate in lambs and young sheep.Crossref | GoogleScholarGoogle Scholar |

Harris PM, Skene PA, Buchan V, Milne E, Calder AG, Anderson SE, Connell A, Lobley GE (1992) Effect of food intake on hind-limb and whole body protein metabolism in young growing sheep: chronic studies based on arterio-difference techniques. British Journal of Nutrition 68, 389–407.
Effect of food intake on hind-limb and whole body protein metabolism in young growing sheep: chronic studies based on arterio-difference techniques.Crossref | GoogleScholarGoogle Scholar | 1445820PubMed |

Harris PM, Lee J, Sinclair BR, Treloar BP, Gurnsey MP (1994) Effect of food intake on energy and protein metabolism in the skin of Romney sheep. British Journal of Nutrition 71, 647–660.
Effect of food intake on energy and protein metabolism in the skin of Romney sheep.Crossref | GoogleScholarGoogle Scholar | 8054321PubMed |

Hegarty RS, Neutze SA, Oddy VH (1999) Effects of protein and energy supply on the growth and carcass composition of lambs from differing nutritional histories. The Journal of Agricultural Science (Camb) 132, 361–375.
Effects of protein and energy supply on the growth and carcass composition of lambs from differing nutritional histories.Crossref | GoogleScholarGoogle Scholar |

Hoskin SO, Savary IC, Zuur G, Lobley GE (2001) Effect of feed intake on ovine hindlimb protein metabolism based on thirteen amino acids and arterio-venous techniques. British Journal of Nutrition 86, 577–585.
Effect of feed intake on ovine hindlimb protein metabolism based on thirteen amino acids and arterio-venous techniques.Crossref | GoogleScholarGoogle Scholar | 11764783PubMed |

Hoskin SO, Savary-Auzeloux IC, Calder AG, Zuur G, Lobley GE (2003) Effect of feed intake on aminao acid transfer across the ovine hindquarters. British Journal of Nutrition 89, 167–179.
Effect of feed intake on aminao acid transfer across the ovine hindquarters.Crossref | GoogleScholarGoogle Scholar | 12575901PubMed |

Koong LJ, Ferrell CL, Nienaber JA (1982) Effects of plane of nutrition on organ size and fasting heat production in swine and sheep. In ‘Proceedings of the 9th symposium on energy metabolism of farm animals’. EAAP Publication 29, pp. 245–248. (Department of Animal Nutrition, Agricultural University of Norway)

Kouakou B, Goetsch AL, Patil AR, Galloway DL, Park KK (1997) Visceral organ mass in wethers consuming different diets with different forage and grain levels. Livestock Production Science 47, 125–137.
Visceral organ mass in wethers consuming different diets with different forage and grain levels.Crossref | GoogleScholarGoogle Scholar |

Loer SA, Scheeren TWL, Tarnow J (1997) How much oxygen does the human lung consume? Anesthesiology 86, 532–537.
How much oxygen does the human lung consume?Crossref | GoogleScholarGoogle Scholar | 9066318PubMed |

McBride BW, Early RJ (1989) Energy expenditure associated with sodium/potassium transport and protein synthesis in skeletal muscle and isolated hepatocytes from hyperthyroid sheep. British Journal of Nutrition 62, 673–682.
Energy expenditure associated with sodium/potassium transport and protein synthesis in skeletal muscle and isolated hepatocytes from hyperthyroid sheep.Crossref | GoogleScholarGoogle Scholar | 2557888PubMed |

McBride BW, Kelly JM (1990) Energy cost of absorption and metabolism in the ruminant gastrointestinal tract and liver: a review Journal of Animal Science 68, 2997–3010.
Energy cost of absorption and metabolism in the ruminant gastrointestinal tract and liver: a reviewCrossref | GoogleScholarGoogle Scholar | 2170320PubMed |

McLeod KR, Baldwin RL (2000) Effects of diet forage : concentrate ratio and metabolizable energy intake on visceral organ growth and in vitro oxidative capacity of gut tissues in sheep. Journal of Animal Science 78, 760–770.
Effects of diet forage : concentrate ratio and metabolizable energy intake on visceral organ growth and in vitro oxidative capacity of gut tissues in sheep.Crossref | GoogleScholarGoogle Scholar | 10764085PubMed |

National Academies of Sciences, Engineering, and Medicine (NASEM) (2016) ‘Nutrient requirements of beef cattle.’ 8th revised edn. (National Academies Press: Washington, DC, USA)

National Research Council (NRC) (1986) ‘Nutrient requirements of beef cattle.’ (National Academy Press: Washington, DC, USA)

Neutze SA, Gooden JM, Oddy VH (1997) Measurement of protein turnover in the small intestine of lambs. 2. Effects of feed intake. Science, Cambridge 128, 233–246.
Measurement of protein turnover in the small intestine of lambs. 2. Effects of feed intake.Crossref | GoogleScholarGoogle Scholar |

Nozière P, Attaix D, Bocquier F, Doreau M (1999) Effects of underfeeding and refeeding on weight and cellularity of splanchnic organs in ewes. Journal of Animal Science 77, 2279–2290.
Effects of underfeeding and refeeding on weight and cellularity of splanchnic organs in ewes.Crossref | GoogleScholarGoogle Scholar | 10462009PubMed |

Oddy VH (1986) Muscle protein metabolism: measurement and manipulation in lambs. PhD Thesis, University of Cambridge, Cambridge, UK.

Oddy VH (1993) Regulation of muscle protein metabolism in sheep and lambs: nutritional, endocrine and genetic aspects. Australian Journal of Agricultural Science 44, 901–913.
Regulation of muscle protein metabolism in sheep and lambs: nutritional, endocrine and genetic aspects.Crossref | GoogleScholarGoogle Scholar |

Oddy VH, Owens PC (1996) Insulin-like growth factor 1 inhibits degradation and improves retention of protein in hindlimb muscle of lambs. The American Journal of Physiology 271, E973–E982.

Oddy VH, Sainz RD (2002) Nutrition for sheep-meat production. In ‘Sheep nutrition’. (Eds M Freer, H Dove) pp. 237–262. (CAB International Publishing: Wallingford, Oxfordshire, UK)

Oddy VH, Gooden JM, Annison EF (1984) Partitioning of nutrients in Merino ewes. 1. Contribution of skeletal muscle, the pregnant uterus and the lactating mammary gland to total energy expenditure. Australian Journal of Biological Sciences 37, 375–388.
Partitioning of nutrients in Merino ewes. 1. Contribution of skeletal muscle, the pregnant uterus and the lactating mammary gland to total energy expenditure.Crossref | GoogleScholarGoogle Scholar | 6536263PubMed |

Oddy VH, Herd RM, Ball AJ, Dicker RW, Robinson DL, Skerritt JW, Alston C, Hammond AJ, Thompson JM (1997a) Prior performance of cattle influences current and future performance, meat yield and quality characteristics: implications for genetic gain. Proceedings of the Australian Association of Animal Breeding and Genetics 12, 738–741.

Oddy VH, Ball AJ, Pleasants AB (1997b) Understanding body composition and efficiency in ruminants: a non-linear approach. Recent Advances in Animal Nutrition in Australia 11, 209–222.

Oltjen JW, Sainz RD (2001) Alternate forms of heat production in ruminant growth and composition models. In ‘Energy metabolism in animals: proceedings of the 15th symposium on energy metabolism in animals’. EAAP publication No. 103. (Eds A Chwalibog, K Jacobsen) pp. 39–42.

Oltjen JW, Bywater AC, Baldwin RL, Garrett WN (1986) Development of a dynamic model of beef cattle growth and composition. Journal of Animal Science 62, 86–97.
Development of a dynamic model of beef cattle growth and composition.Crossref | GoogleScholarGoogle Scholar |

Oltjen JW, Sainz RD, Pleasants AB, Soboleva TK, Oddy VH (2006) Representation of fat and protein gain at low levels of growth and prediction of variable maintenance requirement in a ruminant growth and composition model. In ‘Nutrient digestion and utilization in farm animals: modelling approaches’. (Eds E Kebreab, J Dijkstra, A Bannink, WJJ Gerrits, J France) pp. 144–159. (CAB International Publishing: Wallingford, Oxfordshire, UK)

Ortigues I, Durand D (1995) Adaptation of energy metabolism to undernutrition in ewes. Contribution of portal drained viscera, liver and hindquarters British Journal of Nutrition 73, 209–226.
Adaptation of energy metabolism to undernutrition in ewes. Contribution of portal drained viscera, liver and hindquartersCrossref | GoogleScholarGoogle Scholar | 7718541PubMed |

Reeds PJ, Burrin DG, Davis TA, Stoll B (1998) Amino acid metabolism and the energetics of growth. Archives of Animal Nutrition 51, 187–197.

Reynolds CK (2002) Economics of visceral energy metabolism in ruminants: toll keeping or internal revenue service? Journal of Animal Science 80, E74–E84.
Economics of visceral energy metabolism in ruminants: toll keeping or internal revenue service?Crossref | GoogleScholarGoogle Scholar |

Sainz RD, De la Torre F, Oltjen JW (1995) Compensatory growth and carcass quality in growth-restricted and refed beef steers. Journal of Animal Science 73, 2971–2979.
Compensatory growth and carcass quality in growth-restricted and refed beef steers.Crossref | GoogleScholarGoogle Scholar | 8617667PubMed |

Savary IC, Hoskin SO, Dennison N, Lobley GE (2001) Lysine metabolism across the hindquarters of sheep: effect of intake on transfer from plasma and red blood cells. British Journal of Nutrition 85, 565–573.
Lysine metabolism across the hindquarters of sheep: effect of intake on transfer from plasma and red blood cells.Crossref | GoogleScholarGoogle Scholar | 11348571PubMed |

Soboleva TK, Oddy VH, Pleasants AB, Oltjen JW, Ball AJ, McCall DG (1999) A dynamical model of body composition in sheep. Proceedings of the New Zealand Society of Animal Production 59, 275–278.

Standing Committee on Agriculture (SCA) (1990) ‘Feeding standards for Australian livestock. Ruminants.’ (CSIRO: Melbourne)

Sun W, Goetsch AL, Forster LA, Galloway DL, Lewis PK (1994) Forage and splanchnic tissue mass in growing lambs: effects of dietary forage levels and source on splanchnic tissue mass in growing lambs. British Journal of Nutrition 71, 141–151.
Forage and splanchnic tissue mass in growing lambs: effects of dietary forage levels and source on splanchnic tissue mass in growing lambs.Crossref | GoogleScholarGoogle Scholar | 8142327PubMed |

Teleni E, Annison EF (1986) Development of a sheep hind-limb muscle preparation for metabolic studies. Australian Journal of Biological Sciences 39, 271–281.
Development of a sheep hind-limb muscle preparation for metabolic studies.Crossref | GoogleScholarGoogle Scholar | 3548680PubMed |

Vernet J, Ortigues-Marty I (2006) Conception and development of a bibliographic database of blood nutrient fluxes across organs and tissues in ruminants: data gathering and management prior to meta-analysis. Reproduction, Nutrition, Development 46, 527–546.
Conception and development of a bibliographic database of blood nutrient fluxes across organs and tissues in ruminants: data gathering and management prior to meta-analysis.Crossref | GoogleScholarGoogle Scholar | 17107642PubMed |

Webster AJF, Osuji PO, White F, Ingram JF (1975) The influence of food intake on portal blood flow and heat production in the digestive tract of sheep. British Journal of Nutrition 34, 125–139.
The influence of food intake on portal blood flow and heat production in the digestive tract of sheep.Crossref | GoogleScholarGoogle Scholar |