Effects of 6-Methoxy-l,2,3,4-tetrahydro-b-carboline and Yohimbine on Hypothalamic Monoamine Status and Pituitary Hormone Release in the Rat

GA Smythe; M W Duncan; JE Bradshaw; MV Nicholson

doi:10.1071/bi9830379

RESEARCH ARTICLE

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Effects of 6-Methoxy-l,2,3,4-tetrahydro-b-carboline and Yohimbine on Hypothalamic Monoamine Status and Pituitary Hormone Release in the Rat

GA Smythe, M W Duncan, JE Bradshaw and MV Nicholson

Australian Journal of Biological Sciences 36(4) 379 - 386
Published: 1983

Abstract

Shortly after administration of 6-methoxy-1,2,3,4-tetrahydro-ft-carboline (6-MeOTHBC) and yohimbine to normal or hypothyroid rats [the latter exhibiting chronically elevated levels of serotonin (5-HT) neuronal activity in the hypothalamus] there was a highly significant increase in hypothalamic noradrenaline (NA) activity and in ACTH release concomittant with a reduction in hypothalamic 5-HT activity (P< 0'01) and in growth hormone (GH) (P

https://doi.org/10.1071/BI9830379