The importance of micromonosporae in tropical, sub-tropical, terrestrial and aquatic environments

İpek Kurtböke

doi:10.1071/MA25040

RESEARCH ARTICLE (Open Access)

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The importance of micromonosporae in tropical, sub-tropical, terrestrial and aquatic environments

İpek Kurtböke ^A ^*

+ Author Affiliations

- Author Affiliations

^A School of Science, Technology and Engineering, University of the Sunshine Coast, Maroochydore DC, Qld 4558, Australia.

Assoc. Prof. İpek Kurtböke has been working in the field of biodiscovery and has been an active member of the international actinomycete research community since 1982. She currently conducts research and teaches in the field of environmental and applied microbiology and biotechnology at the University of the Sunshine Coast, Queensland. She has also been an active member of the World Federation of Culture Collections (WFCC) and currently is the President of the Federation. She was also an Editorial Board member of Microbiology Australia for 20 years (2004–2024).

^* Correspondence to: IKurtbok@usc.edu.au

Microbiology Australia https://doi.org/10.1071/MA25040

Submitted: 27 July 2025 Accepted: 7 August 2025 Published: 28 August 2025

© 2025 The Author(s) (or their employer(s)). Published by CSIRO Publishing on behalf of the ASM. This is an open access article distributed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC)

Abstract

The genus Micromonospora (Ørskov 1923) is a Gram-positive, chemo-organotrophic, aerobic actinomycete, the second most predominant genus of the phylum Actinomycetota in natural environments after the genus Streptomyces, and has provided many clinically significant antibiotics, mostly aminoglycosides like gentamicin. This mini review will highlight the occurrence of this genus in diverse environments and its importance for natural product discovery and biotechnology.

Biographies

Assoc. Prof. İpek Kurtböke has been working in the field of biodiscovery and has been an active member of the international actinomycete research community since 1982. She currently conducts research and teaches in the field of environmental and applied microbiology and biotechnology at the University of the Sunshine Coast, Queensland. She has also been an active member of the World Federation of Culture Collections (WFCC) and currently is the President of the Federation. She was also an Editorial Board member of Microbiology Australia for 20 years (2004–2024).

References

1 Genilloud O. Genus Micromonospora. In: Goodfellow M, Kämpfer P, Busse H-J, Trujillo ME, Suzuki K-i, Ludwig W, Whitman WB, editors. Bergey’s Manual of Systematic Bacteriology. Vol. 5. New York, NY: Springer; 2012. pp. 1039–1057.

2 Goodfellow M, Haynes JA. Actinomycetes in marine sediments. In: Ortiz-Ortiz L, Bojalil LF, Yakoleff V, editors. Biological, Biochemical and Biomedical Aspects of Actinomycetes. Orlando: Academic Press, Inc.; 1984. pp. 453–472.

3 Cross T. The actinomycetes II: Growth and examination of actinomycetes-some guidelines. In: Williams ST, Sharpe ME, Holt JG, editors. Bergey’s Manual of Systematic Bacteriology. Vol. 4. Baltimore: Williams and Wilkins; 1989. pp. 2340–2343.

4 Goodfellow M, Cross T. Classification. In: Goodfellow M, Mordarski M, Williams ST, editors. The Biology of Actinomycetes. London: Academic Press; 1984. pp. 7–164.

5 Liu L, Salam N, Jiao JY, Jiang HC, Zhou EM, Yin YR, Ming H, Li WJ (2016) Diversity of culturable thermophilic actinobacteria in hot springs in Tengchong, China and studies of their biosynthetic gene profiles. Microb Ecol 72(1), 150-162.
| Crossref | Google Scholar | PubMed |

6 Kurapova AI, Zenova GM, Sudnitsyn II, Kizilova AK, Manucharova NA, Norovsuren Zh, Zvyagintsev DG (2012) Thermotolerant and thermophilic actinomycetes from soils of Mongolia desert steppe zone. Microbiology 81(1), 98-108.
| Crossref | Google Scholar |

7 Kurapova AI, Zenova GM, Orleanskii VK, Manucharov AS, Norovsuren Zh (2008) Mesophilic and thermotolerant actinomycetes in strongly heated soils. Mosc Univ Soil Sci Bull 63(3), 142-147.
| Crossref | Google Scholar |

8 Ningsih F, Sari DC, Rachmania MK, Yabe S, Yokota A, Oetari A, Sjamsuridzal W (2020) Isolation and 16S rRNA gene sequences analysis of thermophilic Actinobacteria isolated from soil in Cisolok geothermal area, West Java, Indonesia. IOP Conf Ser: Earth Enrivon Sci 457(1), 012015.
| Google Scholar |

9 Mehetre GT, Vinodh JS, Burkul BB, Desai D, Santhakumari B, Dharne MS, Dastager SG (2019) Bioactivities and molecular networking-based elucidation of metabolites of potent actinobacterial strains isolated from the Unkeshwar geothermal springs in India. RSC Adv 9(17), 9850-9859.
| Crossref | Google Scholar | PubMed |

10 Carro L, Pukall R, Spröer C, Kroppenstedt RM, Trujillo ME (2013) Micromonospora halotolerans sp. nov., isolated from the rhizosphere of a Pisum sativum plant. Antonie Van Leeuwenhoek 103(6), 1245-1254.
| Crossref | Google Scholar | PubMed |

11 Zenova GM, Manucharova NA, Zvyagintsev DG (2011) Extremophilic and extremotolerant actinomycetes in different soil types. Eurasian Soil Sci 44(4), 417-436.
| Crossref | Google Scholar |

12 Li L, Mao YJ, Xie QY, Deng Z, Hong K (2013) Micromonospora avicenniae sp. nov., isolated from a root of Avicennia marina. Antonie Van Leeuwenhoek 103(5), 1089-1096.
| Crossref | Google Scholar | PubMed |

13 Wang C, Xu XX, Qu Z, Wang HL, Lin HP, Xie QY, Ruan JS, Hong K (2011) Micromonospora rhizosphaerae sp. nov., isolated from mangrove rhizosphere soil. Int J Syst Evol Microbiol 61(2), 320-324.
| Crossref | Google Scholar | PubMed |

14 Xie QY, Ren J, Li L, Li Y, Deng ZX, Hong K (2016) Micromonospora mangrovi sp. nov., isolated from mangrove soil. Antonie van Leeuwenhoek 109(4), 483-491.
| Crossref | Google Scholar | PubMed |

15 Rajkumar J, Swarnakumar NS, Sivakumar K, Thangaradjou T, Kannan L (2012) Actinobacterial diversity of mangrove environment of the Bhitherkanika mangroves, east coast of Orissa, India. Int J Sci Res Publ 2(2), 1-6.
| Google Scholar |

16 Hidayatullah AR, Sugihartati R, Handijatno D, Chusniati S, Maslachah L, Sarudji S (2020) Isolation of Actinomycetes from mangrove sediments at Ujung Pangkah, Gresik, Indonesia. Ecol Environ Conserv 26, 231-237.
| Google Scholar |

17 Smet A, Parameswari S, Vikineswary S (2002) Diversity of Micromonospora in Malaysian mangrove rhizosphere soil. Malays J Sci 21(1&2), 51-59.
| Google Scholar |

18 Phongsopitanun W, Kudo T, Ohkuma M, Pittayakhajonwut P, Suwanborirux K, Tanasupawat S (2016) Micromonospora sediminis sp. nov., isolated from mangrove sediment. Int J Syst Evol Microbiol 66(8), 3235-3240.
| Crossref | Google Scholar | PubMed |

19 Van Hop D, Sakiyama Y, Binh CT, Otoguro M, Hang DT, Miyadoh S, Luong DT, Ando K (2011) Taxonomic and ecological studies of actinomycetes from Vietnam: isolation and genus-level diversity. J Antibiot 64(9), 599-606.
| Crossref | Google Scholar | PubMed |

20 Eccleston GP, Brooks PR, Kurtböke DI (2008) The occurrence of bioactive micromonosporae in aquatic habitats of the Sunshine Coast in Australia. Mar Drugs 6(2), 243-261.
| Crossref | Google Scholar | PubMed |

21 Hirsch AM, Valdés M (2010) Micromonospora: an important microbe for biomedicine and potentially for biocontrol and biofuels. Soil Biol Biochem 42(4), 536-542.
| Crossref | Google Scholar |

22 Bérdy J (2005) Bioactive microbial metabolites. J Antibiot (Tokyo) 58, 1-26.
| Crossref | Google Scholar | PubMed |

23 Weinstein MJ, Luedemann GM, Oden EM, Wagman GH (1963) Gentamicin, a new broad spectrum antibiotic complex. Antimicrob Agents Chemother (Bethesda) 161, 1-7.
| Google Scholar | PubMed |

24 Wagman GH, Testa RT, Marquez JA (1970) Antibiotic 6640. II Fermentation, isolation, and properties. J Antibiot (Tokyo) 23(11), 555-558.
| Crossref | Google Scholar | PubMed |

25 Weinstein MJ, Marquez JA, Testa RT, Wagman GH, Oden EM, Waitz JA (1970) Antibiotic 6640, a new Micromonospora-produced aminoglycoside antibiotic. J Antibiot (Tokyo) 23, 551-554.
| Crossref | Google Scholar | PubMed |

26 Weinstein MJ, Wagman GH, Marquez JA, Testa RT, Waitz JA (1975) Verdamicin, a new broad spectrum aminoglycoside antibiotic. Antimicrob Agents Chemother 7(3), 246-249.
| Crossref | Google Scholar | PubMed |

27 Nara T, Yamamoto M, Kawamoto I, Takayama K, Okachi R, Takasawa S, Sato T, Sato S (1977) Fortimicins A and B, new aminoglycoside antibiotics I. Producing organism, fermentation and biological properties of fortimicins. J Antibiot (Tokyo) 30(7), 533-540.
| Crossref | Google Scholar | PubMed |

28 Wagman GH, Marquez JA, Watkins PD, Bailey JV, Gentile F, Weinstein MJ (1973) Neomycin production by Micromonospora species 69-683. J Antibiot (Tokyo) 26(12), 732-736.
| Crossref | Google Scholar | PubMed |

29 Okachi R, Kawamoto I, Takasawa S, Yamamoto M, Sato S (1974) A new antibiotic XK-62-2 (Sagamicin) I. Isolation, physicochemical and antibacterial properties. J Antibiot (Tokyo) 27(10), 793-800.
| Crossref | Google Scholar | PubMed |

30 Weinstein MJ, Wagman GH, Marquez JA, Testa RT, Oden E, Waitz JA (1969) Megalomicin, a new macrolide antibiotic complex produced by Micromonospora. J Antibiot (Tokyo) 22(6), 253-258.
| Crossref | Google Scholar | PubMed |

31 Wagman GH, Waitz JA, Marquez J, Murawaski A, Oden EM, Testa RT, Weinstein MJ (1972) A new Micromonospora-produced macrolide antibiotic, rosamicin. J Antibiot (Tokyo) 25(11), 641-646.
| Crossref | Google Scholar | PubMed |

32 Hatano K, Higashide E, Shibata M (1976) Studies on Juvenimicin, a new antibiotic. I taxonomy, fermentation and antimicrobial properties. J Antibiot (Tokyo) 29(11), 1163-1170.
| Crossref | Google Scholar | PubMed |

33 Marquez JA, Kirschner A, Truumees I, et al. Abstr. 172nd Am. Chem. Soc. Meet. MICR 55. New Orleans, Los Angeles: American Chemical Society Publication; 1976.

34 Weinstein MJ, Luedemann GM, Oden EM, Wagman GH (1967) Halomicin, a new Micromonospora-produced antibiotic. Antimicrob Agents Chemother (Bethesda) 7, 435-441.
| Crossref | Google Scholar | PubMed |

35 Weinstein MJ, Wagman GH, Patel MG, Marquez JA. Process for producing rifamycin sv. US Patent 3, 901, 764. 1975.

36 Weinstein MJ, Luedemann GM, Oden EM, Wagman GH (1964) Everninomicin, a new antibiotic complex from Micromonospora carbonacea. Antimicrob Agents Chemother (Bethesda) 10, 24-32.
| Google Scholar | PubMed |

37 Wagman GH, Marquez JA, Watkins PD, Gentile F, Murawski A, Patel M, Weinstein MJ (1976) A new actinomycin complex produced by a Micromonospora species: fermentation, isolation, and characterization. Antimicrob Agents Chemother (Bethesda) 9(3), 465-469.
| Crossref | Google Scholar | PubMed |

38 Wagman GH, Weinstein MJ (1980) Antibiotics from Micromonospora. Ann Rev Microbiol 34, 537-557.
| Crossref | Google Scholar | PubMed |

39 Boumehira AZ, El-Enshasy HA, Hacène H, Elsayed EA, Aziz R, Park EY (2016) Recent progress on the development of antibiotics from the genus Micromonospora. Biotechnol Bioprocess Eng 21(2), 199-223.
| Crossref | Google Scholar |

40 He H, Ding WD, Bernan VS, Richardson AD, Ireland CM, Greenstein M, Ellestad GA, Carter GT (2001) Lomaiviticins A and B, potent antitumor antibiotics from Micromonospora lomaivitiensis. J Am Chem Soc 123(22), 5362-5363.
| Crossref | Google Scholar | PubMed |

41 Back CR, Stennett HL, Williams SE, Wang L, Ojeda Gomez J, Abdulle OM, Duffy T, Neal C, Mantell J, Jepson MA, Hendry KR, Powell D, Stach J, Essex-Lopresti AE, Willis CL, Curnow P, Race PR (2021) A new Micromonospora strain with antibiotic activity isolated from the microbiome of a mid-Atlantic deep-sea sponge. Mar Drugs 19(2), 105.
| Crossref | Google Scholar | PubMed |

42 Cheng Z, Zhang Q, Peng J, Zhao X, Ma L, Zhang C, Zhu Y (2023) Genomics-driven discovery of benzoxazole alkaloids from the marine-derived micromonospora sp. SCSIO 07395. Molecules 28(2), 821.
| Crossref | Google Scholar | PubMed |

43 Kokkini M, González Heredia C, Oves-Costales D, de la Cruz M, Sánchez P, Martín J, Vicente F, Genilloud O, Reyes F (2022) Exploring Micromonospora as phocoenamicins producers. Mar Drugs 20(12), 769.
| Crossref | Google Scholar | PubMed |

44 Kokkini M, Oves-Costales D, Sánchez P, Melguizo Á, Mackenzie TA, Pérez-Bonilla M, Martín J, Giusti A, de Witte P, Vicente F, Genilloud O, Reyes F (2023) New phocoenamicin and maklamicin analogues from cultures of three marine-derived Micromonospora strains. Mar Drugs 21(8), 443.
| Crossref | Google Scholar | PubMed |

45 Ismet A, Vikineswary S, Paramaswari S, Wong WH, Ward A, Seki T, Fiedler HP, Goodfellow M (2004) Production and chemical characterization of antifungal metabolites from Micromonospora sp. M39 isolated from mangrove rhizosphere soil. World J Microbiol Biotechnol 20(5), 523-528.
| Crossref | Google Scholar |

46 Sarveswari HB, Kalimuthu S, Shanmugam K, Neelakantan P, Solomon AP (2020) Exploration of anti-infectives from mangrove-derived Micromonospora sp. RMA46 to combat Vibrio cholerae pathogenesis. Front Microbiol 11, 1393.
| Crossref | Google Scholar | PubMed |

47 Wang RJ, Zhang SY, Ye YH, Yu Z, Qi H, Zhang H, Xue ZL, Wang JD, Wu M (2019) Three new isoflavonoid glycosides from the mangrove-derived actinomycete Micromonospora aurantiaca 110B. Mar Drugs 17(5), 294.
| Crossref | Google Scholar | PubMed |

48 Pradhan D, Das MT (2025) Antimicrobial potential and extracellular metabolite profiling of bichitrapur mangrove sediment derived Micromonospora sp. BSS-D-04 and Streptomyces sp. BSS-D-05 using LC–MS/MS and GC–MS analysis. Braz J Microbiol 2025, 1-17.
| Crossref | Google Scholar | PubMed |

49 Anggelina AC, Pringgenies D, Setyati WA (2021) Presence of biosynthetic gene clusters (nrps/pks) in actinomycetes of mangrove sediment in Semarang and Karimunjawa, Indonesia. Environ Nat Resour J 19(5), 391-401.
| Crossref | Google Scholar |

50 Lee LH, Zainal N, Azman AS, Eng SK, Goh BH, Yin WF, Ab Mutalib NS, Chan KG (2014) Diversity and antimicrobial activities of actinobacteria isolated from tropical mangrove sediments in Malaysia. Sci World J 2014(1), 698178.
| Crossref | Google Scholar | PubMed |

51 Songsumanus A (2013) Characterization and screening of antimicrobial activity of Micromonospora strains from Thai soils. Malays J Microbiol 9(3), 260-269.
| Crossref | Google Scholar |

52 Vu TTH (2022) Screening of actinomycetes from Ninh Thuan and Binh Thuan Seas for antimicrobial producers. Vietnam J Mar Sci Technol 22(4), 423-432.
| Crossref | Google Scholar |

53 Simmons CW, Reddy AP, D'haeseleer P, Khudyakov J, Billis K, Pati A, Simmons BA, Singer SW, Thelen MP, VanderGheynst JS (2014) Metatranscriptomic analysis of lignocellulolytic microbial communities involved in high-solids decomposition of rice straw. Biotechnol Biofuels 7(1), 495.
| Crossref | Google Scholar | PubMed |

54 Kumas A, Ertekin SG, Gurbanov R, Simsek YE, Kocak FO (2023) Effect of Micromonospora sp. KSC08 on nitrogen conservation throughout composting. Biomass Convers Biorefin 13(3), 2375-2390.
| Crossref | Google Scholar |

55 Nor Hasan HN, Abdullah MDD, Saidin JB (2024) Antimicrobial and enzymatic activities of mangrove-associated actinomycetes. Malays Appl Biol 53(3), 219-228.
| Crossref | Google Scholar |

56 El-Tarabily KA, Sykes ML, Kurtböke ID, Hardy GESJ, Barbosa AM, Dekker RFH (1996) Synergistic effects of a cellulase-producing Micromonospora carbonaceae and an antibiotic-producing Streptomyces violascens on the suppression of Phytophthora cinnamomi root rot of Banksia grandis. Canad J Bot 74, 618-624.
| Crossref | Google Scholar |

57 El-Tarabily KA, Soliman MH, Nassar AH, Al-Hassani HA, Sivasithamparam K, McKenna F, Hardy GESJ (2000) Biological control of Sclerotinia minor using a chitinolytic bacterium and actinomycetes. Plant Pathol 49(5), 573-583.
| Crossref | Google Scholar |

58 Kurtböke Dİ, French, JRJ, Hayes, RA, Quinn, RJ. Eco-taxonomic insights into actinomycete symbionts of termites for discovery of novel bioactive compounds. In: Mukherjee J, editor. Biotechnological Applications of Biodiversity. Advances in Biochemical Engineering/Biotechnology. Vol. 147. Berlin Heidelberg: Springer-Verlag; 2014. pp. 111–135. 10.1007/10_2014_270

59 Tiong E, Koo YS, Bi J, Koduru L, Koh W, Lim YH, Wong FT (2023) Expression and engineering of PET-degrading enzymes from Microbispora, Nonomuraea, and Micromonospora. Appl Environ Microbiol 89(11), e00632-23.
| Crossref | Google Scholar | PubMed |

60 Abdelmohsen UR, Szesny M, Othman EM, Schirmeister T, Grond S, Stopper H, Hentschel U (2012) Antioxidant and anti-protease activities of diazepinomicin from the sponge-associated Micromonospora strain RV115. Mar Drugs 10(10), 2208-2221.
| Crossref | Google Scholar | PubMed |

61 Wagman GH, Gannon RD, Weinstein MJ (1969) Production of vitamin B12 by Micromonospora. Appl Microbiol 17(4), 648-649.
| Crossref | Google Scholar | PubMed |

62 Demain AL (2000) Small bugs, big business: the economic power of the microbe. Biotechnol Adv 18(6), 499-514.
| Crossref | Google Scholar | PubMed |

63 Carro L, Nouioui I, Sangal V, Meier-Kolthoff JP, Trujillo ME, Montero-Calasanz M, Sahin N, Smith DL, Kim KE, Peluso P, Deshpande S, Woyke T, Shapiro N, Kyrpides NC, Klenk HP, Göker M, Goodfellow M (2018) Genome-based classification of micromonosporae with a focus on their biotechnological and ecological potential. Sci Rep 8(1), 525.
| Crossref | Google Scholar | PubMed |

64 Han J-R, Li S, Lian W-H, Xu L, Duan L, Li J-L, Feng C-Y, Shi G-Y, Liu W-L, Wei Q-C, Li W-J, Dong L (2025) Multi‐omics analyses uncovering the biosynthetic potential of novel Micromonospora species isolated from desert and marine habitats. J Syst Evol
| Crossref | Google Scholar |

65 Yan S, Zeng M, Wang H, Zhang H (2022) Micromonospora: a prolific source of bioactive secondary metabolites with therapeutic potential. J Med Chem 65(13), 8735-8771.
| Crossref | Google Scholar | PubMed |